Evidence map›Paper›PMID 37380767›Full record

ArticleNature2023

A spatially resolved single-cell genomic atlas of the adult human breast.

Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy H Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei and 30 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. celltypeEnrich: a consensus-based scRNA-seq cluster annotation tool.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
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  8. Article
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  10. Article
  11. Article
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  14. Article
  15. Article
  16. Article
  17. An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Tapsi Kumar *Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-2825-3387
Kevin Nee *Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Runmin Wei *Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Siyuan He *Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Quy H Nguyen *Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Shanshan BaiDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Kerrigan BlakeDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Maren PeinDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-7906-5960
Yanwen GongDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Emi SeiDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Min HuDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Anna K CasasentDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Aatish ThennavanDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Jianzhuo LiDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Tuan TranDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA.
Ken ChenDepartment of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4013-5279
Benedikt NilgesResolve Biosciences, Monheim am Rhein, Germany.
Nachiket KashikarResolve Biosciences, Monheim am Rhein, Germany.
Oliver BraubachAkoya Biosciences, Menlo Park, CA, USA.
Bassem Ben CheikhAkoya Biosciences, Menlo Park, CA, USA.
Nadya NikulinaAkoya Biosciences, Menlo Park, CA, USA.
Hui ChenDepartment of Pathology, UT MD Anderson Cancer Center, Houston, TX, USA.
Mediget TeshomeDepartment of Breast Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA.
Brian MenegazDepartment of Pathology and Immunology, Baylor Medical College, Houston, TX, USA.ORCID 0000-0002-3020-5790
Huma JavaidDepartment of Pathology and Immunology, Baylor Medical College, Houston, TX, USA.
Chandandeep NagiDepartment of Pathology and Immunology, Baylor Medical College, Houston, TX, USA.
Jessica MontalvanDepartment of Pathology and Immunology, Baylor Medical College, Houston, TX, USA.
Tatyana LevDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Sharmila MallyaDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Delia F TifreaChao Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
Robert EdwardsChao Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
Erin LinChao Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
Ritesh ParajuliChao Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
Summer HansonDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.ORCID 0000-0002-4106-9819
Sebastian WinocourDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Alastair ThompsonDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.
Bora LimDepartment of Medicine, Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4182-6058
Devon A LawsonDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA. dalawson@uci.edu.ORCID 0000-0003-1692-0517
Kai KessenbrockDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. kai.kessenbrock@uci.edu.ORCID 0000-0003-0410-6104
Nicholas NavinDepartment of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, USA. nnavin@mdanderson.org.ORCID 0000-0002-2106-8624

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Microenvironmental regulation of breast tumorigenesisR01CA234496 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kai Kessenbrock · 2019 to 2026
$4.3M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
DELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICSR01CA236864 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2020 to 2024
$2.3M
INVESTIGATING TUMOR INITIATION AND INVASION IN PREMALIGNANT BREAST CANCER WITH SPATIAL SINGLE CELL GENOMICSR01CA240526 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAVIN, NICHOLAS · 2019 to 2023
$1.8M
Investigating the role of pericytes as regulators of breast tissue homeostasis and cancer.F30CA243419 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI NEE, KEVIN · 2019 to 2022
$151k
NCI NIH HHS F30 CA243419NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA234496NCI NIH HHS R01 CA236864NCI NIH HHS R01 CA240526NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

The adult human breast is comprised of an intricate network of epithelial ducts and lobules that are embedded in connective and adipose tissue

Indexed as

BreastGene Expression ProfilingSingle-Cell AnalysisAdultBreast NeoplasmsEndothelial CellsEpithelial CellsFemaleGenomicsHumansImmunity

Identifiers

PMID37380767
PMCPMC11443819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.