ArticleNature2023
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 1 pooled it
52.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 1 synthesis or guideline pooled it, 210 citations in OpenAlex.
- Circulating growth differentiation factor-15 concentration and hypertension risk: a dose-response meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Effect of 6-week tadalafil treatment on blood-based biomarkers of neurodegeneration: A post-hoc analysis of a randomized controlled trial.Journal of Alzheimer's disease : JAD · 2026Trial
- A crucial role for novel miR-12137-3p in supporting weight gain in treatment naïve HIV-infected patients on antiretroviral therapies.Journal of translational medicine · 2026Trial
- High-Intensity Circuit Training Plus Sleep Health Intervention for Sleep Improvement: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans.Frontiers in endocrinology · 2026Trial
- Effects of exercise conducted prior to phenylketonuria-type meal on appetite, satiety hormones and energy expenditure: a randomised cross-over trial.European journal of clinical nutrition · 2025Trial
- Effects of a two-week modified ketogenic diet on circulating lipoprotein subclasses, GDF15, and FGF21 in obese adults.Journal of translational medicine · 2025Trial
- The effect of exercise on GDF-15 levels in individuals with prediabetes: A randomized controlled trial.Journal of diabetes investigation · 2025Trial
- Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy.Radiation oncology (London, England) · 2024Trial
- Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus.Experimental physiology · 2024Trial
- Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.Journal of cachexia, sarcopenia and muscle · 2024Trial
- Trial
- Exerkines in precision management of metabolic diseases.Chinese medical journal · 2026Review
- Lipid sensing and brain hormone receptors in food intake and glucose regulation.Nature reviews. Endocrinology · 2026Review
- Circulating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.GeroScience · 2026Article
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.Journal of bioenergetics and biomembranes · 2026Review
- Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure.ESC heart failure · 2026Article
- Review
- Beyond eGFR and Albuminuria: Biological Pathways and Multiomics in Cardiovascular-Kidney-Metabolic Disease.Kidney international reports · 2026Review
104 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
29 authors at 11 institutions in 5 countries.
Dongdong WangCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-6195-4428
Logan K TownsendCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Geneviève J DesOrmeauxDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Sara M FrangosDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Battsetseg BatchuluunCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Lauralyne DumontDepartment of Pharmacology-Physiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Rune Ehrenreich KuhreGlobal Obesity and Liver Disease Research, Global Drug Discovery, Novo Nordisk, Maaloev, Denmark.ORCID 0000-0003-4787-340X
Elham AhmadiCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-0472-4615
Sumei HuKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing, China.ORCID 0000-0002-3618-4492
Irena A RebalkaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-4732-5473
Jaya GautamCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Maria Joy Therese JabileCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Chantal A PileggiDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Sonia RehalCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Eric M DesjardinsCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Evangelia E TsakiridisCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
James S V LallyCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Emma Sara JuracicDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
A Russell TuplingDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0002-3895-6767
Hertzel C GersteinCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-8072-2836
Guillaume ParéCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-6795-4760
Theodoros TsakiridisCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Mary-Ellen HarperDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0003-3864-5886
Thomas J HawkeDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
John R SpeakmanShenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-2457-1823
Denis P BlondinDepartment of Pharmacology-Physiology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID 0000-0001-6805-0985
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Sebastian Beck JørgensenGlobal Obesity and Liver Disease Research, Global Drug Discovery, Novo Nordisk, Maaloev, Denmark.ORCID 0000-0002-9648-0971
Gregory R SteinbergCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.ORCID 0000-0001-5425-8275
McMaster University · CAUniversity of Guelph · CAPopulation Health Research Institute · CAUniversité de Sherbrooke · CAUniversity of Ottawa · CAUniversity of Waterloo · CABeijing Technology and Business University · CNKunming Institute of Zoology · CNMcMaster University Medical Centre · CANovo Nordisk (Denmark) · DKUniversity of Copenhagen · DK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes
Indexed as
Energy MetabolismGrowth Differentiation Factor 15Muscle, SkeletalWeight LossAnimalsAppetite DepressantsCaloric RestrictionDiabetes Mellitus, Type 2Diet, High-FatEatingGlial Cell Line-Derived Neurotrophic Factor ReceptorsHumansMiceNon-alcoholic Fatty Liver DiseaseReceptors, Adrenergic, betaAppetite DepressantsGDF15 protein, humanGFRAL protein, mouseGlial Cell Line-Derived Neurotrophic Factor ReceptorsGrowth Differentiation Factor 15Receptors, Adrenergic, beta
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.