SynthesisTranslational psychiatry2023
The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis.
Synthesis in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Nature genetics · 2025Pooled it
- Prevalence of obsessive-compulsive disorder in the older person: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- A Multidimensional Data Set for Obsessive-Compulsive Disorder to Strengthen Research and Care: A Cross-Sectional Delphi Study.Health science reports · 2026Article
- "It Doesn't Matter Where OCD Comes From," or Does It?Current psychiatry reports · 2026Review
- Understanding Sex and Gender Effects on Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Clinical Presentation and Risk Factors.Biological psychiatry global open science · 2026Review
- Shared genetic and environmental influences between the broad avoidant/restrictive food intake disorder phenotype and neurodevelopmental traits: a twin study.medRxiv : the preprint server for health sciences · 2026Article
- Increased Serum GLO-1 Levels Are Associated With the Pathophysiology and Development of Obsessive-Compulsive Disorder: Findings From a Case-Control Study.Health science reports · 2026Article
- Familial Clustering of Hypochondriasis.Psychotherapy and psychosomatics · 2026Article
- Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026Article
- Review
- Reducing anxiety and depression in OCD: a randomized controlled trial of exposure and response prevention therapy.Health psychology report · 2026Article
- Rare coding variation in OCD implicates shared genes with other psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.medRxiv : the preprint server for health sciences · 2025Article
- The risk factors of obsessive-compulsive disorder: a cross-sectional study in Southwestern China.BMC psychiatry · 2025Article
- Biological, Psychosocial, and Microbial Determinants of Childhood-Onset Obsessive-Compulsive Disorder: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Decision-making using the Iowa gambling test in unaffected first-degree relatives of obsessive-compulsive disorder: Comparison with healthy controls and patients with obsessive-compulsive disorder.Journal of neuropsychology · 2025Article
- Association between bullying victimization and obsessive-compulsive disorder: a population-based, genetically informative study.Molecular psychiatry · 2025Article
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
The first systematic review and meta-analysis of obsessive-compulsive disorder (OCD) genetic epidemiology was published approximately 20 years ago. Considering the relevance of all the studies published since 2001, the current study aimed to update the state-of-art knowledge on the field. All published data concerning the genetic epidemiology of OCD from the CENTRAL, MEDLINE, EMBASE, BVS, and OpenGrey databases were searched by two independent researchers until September 30, 2021. To be included, the articles had to fulfill the following criteria: OCD diagnosis provided by standardized and validated instruments; or medical records; inclusion of a control group for comparison and case-control, cohort or twin study designs. The analysis units were the first-degree relatives (FDRs) of OCD or control probands and the co-twins in twin pairs. The outcomes of interest were the familial recurrence rates of OCD and the correlations of OCS in monozygotic compared with dizygotic twins. Nineteen family, twenty-nine twin, and six population-based studies were included. The main findings were that OCD is a prevalent and highly familial disorder, especially among the relatives of children and adolescent probands, that OCD has a phenotypic heritability of around 50%; and that the higher OCS correlations between MZ twins were mainly due to additive genetic or to non-shared environmental components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.