Evidence map›Paper›PMID 37380019›Full record

ArticleContemporary clinical trials2023

The effects of the DASH dietary pattern on clinical outcomes and quality of life in adults with uncontrolled asthma: Design and methods of the ALOHA Trial.

S M Nyenhuis, A Dixon, L Wood, N Lv, N Wittels, C R Ronneberg, L Xiao, S Dosala, A Marroquin, A Barve and 6 more

Erratum issued Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05251402 (The ALOHA Trial), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05251402 phase2 / phase3completednot on this map

The ALOHA Trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2022 to 2026Enrolled323ConditionsAsthmaArmsGroup A - Patient Education, Group B - Patient Education with Nutrition Counseling
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

S M NyenhuisSection of Allergy and Immunology, University of Chicago, Chicago, IL, USA.
A DixonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Burlington, VT, USA.
L WoodUniversity of Newcastle, Newcastle, Australia.
N LvDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
N WittelsDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
C R RonnebergDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
L XiaoDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, United States of America.
S DosalaDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
A MarroquinDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
A BarveDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
W HarmonDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
M PoynterDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
A ParikhDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
C A CamargoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
L AppelWelch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA.
J MaDivision of Academic Internal Medicine, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA. Electronic address: maj2015@uic.edu.
University of Illinois Chicago · USBrigham and Women's Hospital · USJohns Hopkins University · USStanford University · USUniversity of Chicago · USUniversity of Newcastle Australia · AUUniversity of Vermont · US

Funding

The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary PatternR33HL155160 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN · 2022 to 2025
$3.1M
The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary PatternR61HL155160 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN · 2021 to 2021
$826k
NHLBI NIH HHS R33 HL155160NHLBI NIH HHS R61 HL155160
6 · The paper itself

Abstract

backgroundPoor diet quality is an important risk factor for increased asthma prevalence and poor asthma control. To address the question of whether adults with asthma can benefit from following a healthy diet, this trial will test the efficacy and mechanisms of action of a behavioral intervention promoting the Dietary Approaches to Stop Hypertension (DASH) dietary pattern with sodium reduction among patients with uncontrolled asthma.

methodsIn this 2-arm randomized clinical trial, 320 racially/ethnically and socioeconomically diverse adults with uncontrolled asthma on standard controller therapy will be randomized to either a control or an intervention group and assessed at baseline, 3, 6 and 12 months. Control and intervention participants will receive education on lung health, asthma, and other general health topics; additionally, the intervention group will receive DASH behavioral counseling over 12 months. The primary hypothesis is that the DASH behavioral intervention, compared with the education-only control, will lead to significantly more participants with minimum clinically important improvement (responders) in asthma-specific quality of life at 12 months. Secondary hypotheses will test the intervention effects on other asthma (e.g., asthma control, lung function) and non-asthma outcomes (e.g., quality of life). Additionally, therapeutic (e.g., short chain fatty acids, cytokines) and nutritional biomarkers (e.g., dietary inflammatory index, carotenoids) will be assessed to understand the mechanisms of the intervention effect.

conclusionThis trial can substantially advance asthma care by providing rigorous evidence on the benefits of a behavioral dietary intervention and mechanistic insights into the role of diet quality in asthma. CLINICALTRIALS: gov #: NCT05251402.

Indexed as

AsthmaDietary Approaches To Stop HypertensionHypertensionAdultBehavior TherapyDietHumansQuality of LifeRandomized Controlled Trials as TopicAsthmaDASHDietary patternQuality of Life

Identifiers

PMID37380019
PMCPMC10629484
OpenAlexW4382051952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.