Evidence map›Paper›PMID 37379571›Full record

ArticleBiochemistry2023

Negative Charges Introduced Near the IT Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments.

Li Zhu, Maicon Landim-Vieira, Michelle Rodriguez Garcia, Jose R Pinto, Joseph M Chalovich

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Li ZhuDepartment of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, United States.
Maicon Landim-VieiraDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32304, United States.
Michelle Rodriguez GarciaDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32304, United States.
Jose R PintoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32304, United States.ORCID 0000-0001-9092-4976
Joseph M ChalovichDepartment of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, United States.ORCID 0000-0002-1243-4055
Florida State University · USEast Carolina University · US

Funding

The mechanisms of cardiac thin filament regulation in health and disease.R01HL160966 · NHLBI · OLD DOMINION UNIVERSITY · PI CHASE, P. BRYANT, GALKIN, VITOLD · 2022 to 2025
$2.3M
NHLBI NIH HHS R01 HL160966
6 · The paper itself

Abstract

The disordered and basic C-terminal 14 residues of human troponin T (TnT) are essential for full inhibition of actomyosin ATPase activity at low Ca

Indexed as

ActinsTroponin TActin CytoskeletonAdenosine TriphosphatasesCalciumHumansMyosinsTropomyosinActinsAdenosine TriphosphatasesCalciumMyosinsTropomyosinTroponin T

Identifiers

PMID37379571
PMCPMC10576618
OpenAlexW4382363219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.