Evidence map›Paper›PMID 37379524›Full record

ArticleInorganic chemistry2023

ATCUN-like Copper Site in βB2-Crystallin Plays a Protective Role in Cataract-Associated Aggregation.

Martin E Tovar-Ramírez, Nils Schuth, Oscar Rodríguez-Meza, Thomas Kroll, Gloria Saab-Rincon, Miguel Costas, Kirsten Lampi, Liliana Quintanar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Martin E Tovar-RamírezDepartment of Chemistry, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City 07360, Mexico.
Nils SchuthDepartment of Chemistry, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City 07360, Mexico.
Oscar Rodríguez-MezaFacultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0003-1183-8821
Thomas KrollStanford Synchrotron Radiation Lightsource (SSRL), SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
Gloria Saab-RinconDepartment of Biocatalysis and Cellular Engineering, Instituto de Biotecnología, Universidad Nacional Autónoma de Mexico, Cuernavaca, Morelos 62210, Mexico.ORCID 0000-0002-5251-1000
Miguel CostasFacultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Kirsten LampiIntegrative Biosciences, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0002-7906-6699
Liliana QuintanarDepartment of Chemistry, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City 07360, Mexico.ORCID 0000-0003-3090-7175
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXUniversidad Nacional Autónoma de México · MXOregon Health & Science University · USSLAC National Accelerator Laboratory · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Aggregation of Deamidated Crystallins as a Major Cause of CataractsR01EY027012 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAMPI, KIRSTEN JEANNE · 2016 to 2024
$1.9M
NEI NIH HHS R01 EY027012NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

Cataract is the leading cause of blindness worldwide, and it is caused by crystallin damage and aggregation. Senile cataractous lenses have relatively high levels of metals, while some metal ions can directly induce the aggregation of human γ-crystallins. Here, we evaluated the impact of divalent metal ions in the aggregation of human βB2-crystallin, one of the most abundant crystallins in the lens. Turbidity assays showed that Pb

Indexed as

CataractCrystallinsAmino Acid Sequencebeta-Crystallin B ChainCopperHumansIonsbeta-crystallin B2beta-Crystallin B ChainCopperCrystallinsIons

Identifiers

PMID37379524
PMCPMC11156493
OpenAlexW4382361952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.