Evidence map›Paper›PMID 37379434›Full record

ArticleAnalytical chemistry2023

Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase.

Timothy R O'Leary, Deepa Balasubramaniam, Kristin Hughes, Denisa Foster, Jeffrey Boyles, Kristina Coleman, Patrick R Griffin

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Timothy R O'LearyDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida 33458, United States.
Deepa BalasubramaniamLilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States.
Kristin HughesLilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States.
Denisa FosterLilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States.
Jeffrey BoylesEli Lilly and Company, Indianapolis, Indiana 46225, United States.
Kristina ColemanLilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States.
Patrick R GriffinDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida 33458, United States.ORCID 0000-0002-3404-690X
Eli Lilly (United States) · USThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Funding

Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Bruce Edward Torbett · 2022 to 2026
$36.7M
NIAID NIH HHS U54 AI170855
6 · The paper itself

Abstract

Hydrogen-deuterium exchange coupled with mass spectrometry (HDX-MS) is widely used for monoclonal antibody (mAb) epitope mapping, which aids in the development of therapeutic mAbs and vaccines, as well as enables the understanding of viral immune evasion. Numerous mAbs are known to recognize N-glycosylated epitopes and to bind in close proximity to an

Indexed as

COVID-19HydrogenAntibodies, MonoclonalDeuteriumDeuterium Exchange MeasurementEpitope MappingEpitopesGlycoside HydrolasesHumansSARS-CoV-2Antibodies, MonoclonalDeuteriumEpitopesGlycoside HydrolasesHydrogen

Identifiers

PMID37379434
PMCPMC10830291
OpenAlexW4382363143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.