Evidence map›Paper›PMID 37379380›Full record

ArticleScience advances2023

Scale-free correlations and potential criticality in weakly ordered populations of brain cancer cells.

Kevin B Wood, Andrea Comba, Sebastien Motsch, Tomás S Grigera, Pedro R Lowenstein

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin B WoodDepartment of Biophysics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0985-7401
Andrea CombaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3398-5753
Sebastien MotschSchool of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA.
Tomás S GrigeraInstituto de Física de Líquidos y Sistemas Biológicos (IFLySiB), Buenos Aires, Argentina.ORCID 0000-0002-3165-4838
Pedro R LowensteinDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8427-4409

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Spatiotemporal Dynamics of Collective Antibiotic Resistance in Microbial CommunitiesR35GM124875 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOOD, KEVIN · 2017 to 2024
$2.7M
Systemic Delivery of Targeted Bi-Compartmental Nanoparticles for Glioblastoma Therapeutics (Supplement)R01NS124167 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, JOERG LAHANN · 2022 to 2026
$2.6M
Novel nano-vaccine technology for inducing immunity against gliomasR01NS122536 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G, MOON, JAMES J. · 2021 to 2025
$2.6M
The Role of Collagen and its Signaling Mechanisms in Glioma Progression and Invasion.R01NS122234 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pedro R. Lowenstein · 2022 to 2026
$2.4M
Identifying intercellular circuits driving cell phenotypes within a nicheR01CA243916 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JERUSS, JACQUELINE SARA, SHEA, LONNIE D · 2019 to 2023
$2.3M
Interactions between the tumor cells and the neuro-immune microenvironment in mutant IDH1 gliomas: implications for therapeuticsR01NS105556 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2018 to 2021
$1.9M
Role of the collagen receptor LAIR-1 in glioma progression and the tumor immune microenvironmentR01NS127378 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pedro R. Lowenstein · 2022 to 2026
$1.8M
Chemo-immunotherapy strategy for pediatric high grade gliomaR21NS123879 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G, SCHWENDEMAN, ANNA · 2021 to 2021
$429k
NCATS NIH HHS UL1 TR002240NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA243916NIGMS NIH HHS R35 GM124875NINDS NIH HHS R01 NS105556NINDS NIH HHS R01 NS122234NINDS NIH HHS R01 NS122536NINDS NIH HHS R01 NS124167NINDS NIH HHS R01 NS127378NINDS NIH HHS R21 NS123879
6 · The paper itself

Abstract

Collective behavior spans several orders of magnitude of biological organization, from cell colonies to flocks of birds. We used time-resolved tracking of individual glioblastoma cells to investigate collective motion in an ex vivo model of glioblastoma. At the population level, glioblastoma cells display weakly polarized motion in the (directional) velocities of single cells. Unexpectedly, fluctuations in velocities are correlated over distances many times the size of a cell. Correlation lengths scale linearly with the maximum end-to-end length of the population, indicating that they are scale-free and lack a characteristic decay scale other than the size of the system. Last, a data-driven maximum entropy model captures statistical features of the experimental data with only two free parameters: the effective length scale (

Indexed as

Brain NeoplasmsGlioblastomaBrainEntropyHumansMotion

Identifiers

PMID37379380
PMCPMC10306295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.