Evidence map›Paper›PMID 37379094›Full record

ArticleAnesthesia progress2023

Involvement of α- and β-Adrenergic Receptors in Skeletal Muscle Blood Flow Changes During Hyper-/Hypocapnia in Anesthetized Rabbits.

Kyotaro Koshika, Rumi Kaneko, Mai Shionoya, Kotaro Shimizu, Yuka Sendai, Nobutaka Matsuura, Yui Akiike, Tatsuya Ichinohe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesia progress, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kyotaro KoshikaAssociate Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Rumi KanekoPostgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Mai ShionoyaPostgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Kotaro ShimizuPostgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Yuka SendaiPostgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Nobutaka MatsuuraPostgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Yui AkiikeSenior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Tatsuya IchinoheProfessor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.
Tokyo Dental College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the involvement of α1- and β2-adrenergic receptors in skeletal muscle blood flow changes during variations in ETCO2.

methodsForty Japanese White rabbits anesthetized with isoflurane were randomly allocated to 1 of 5 groups: phentolamine, metaproterenol, phenylephrine, butoxamine, and atropine. Heart rate (HR), systolic blood pressure (SBP), common carotid artery blood flow (CCBF), masseter muscle tissue blood flow (MBF), and quadriceps muscle tissue blood flow (QBF) were recorded and analyzed at 3 periods: (1) baseline, (2) during hypercapnia (phentolamine and metaproterenol groups) or hypocapnia (phenylephrine, butoxamine, and atropine groups), and (3) during or after receiving vasoactive agents.

resultsMBF and QBF decreased during hypercapnia. The decrease in MBF was smaller than that in QBF. SBP and CCBF increased, while HR decreased. Both MBF and QBF recovered to their baseline levels after phentolamine administration. MBF became greater than its baseline level, while QBF did not fully recover after metaproterenol administration. MBF and QBF increased during hypocapnia. The increase rate in MBF was larger than that in QBF. HR, SBP, and CCBF did not change. Both MBF and QBF decreased to ∼90% to 95% of their baseline levels after phenylephrine or butoxamine administration. Atropine showed no effects on MBF and QBF.

conclusionThese results suggest the skeletal muscle blood flow changes observed during hypercapnia and hypocapnia may mainly involve α1-adrenergic but not β2-adrenergic receptor activity.

Indexed as

HypercapniaHypocapniaAnimalsAtropine DerivativesBlood PressureButoxamineMetaproterenolMuscle, SkeletalPhentolaminePhenylephrineRabbitsReceptors, Adrenergic, betaRegional Blood FlowAtropine DerivativesButoxamineMetaproterenolPhentolaminePhenylephrineReceptors, Adrenergic, betaAdrenergic receptorHypercapniaHypocapniaSkeletal muscle blood flow

Identifiers

PMID37379094
PMCPMC10328189
OpenAlexW4382345079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.