Evidence map›Paper›PMID 37378949›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.

Ahmad Najafi, Matine Sabaghi, Hossein Asgarian-Omran, Reza Valadan, Ramin Shekarriz, Ehsan Zaboli, Ghasem Janbabai, Mohsen Tehrani

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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ahmad NajafiDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Matine SabaghiDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Hossein Asgarian-OmranDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Reza ValadanDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ramin ShekarrizDepartment of Hematology and Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Ehsan ZaboliDepartment of Hematology and Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0003-4009-717x
Ghasem JanbabaiDepartment of Hematology and Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Mohsen TehraniDepartment of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBATF, as a transcription factor, and CD112, as a receptor for TIGIT, are involved in T-cell exhaustion. We investigated BATF and CD112 gene expression in the peripheral blood mononuclear cells from CLL patients and healthy subjects.

methodsIn a case-control study, 33 patients with CLL and 20 sex- and age-matched healthy individual were enrolled. Diagnosis and classification of patients was done according to immunophenotyping via flow cytometry and RAI staging system, respectively. Relative mRNA expression of BATF and CD112 was measured using qRT-PCR.

resultOur results showed that the expression of BATF and CD112 in CLL samples were significantly decreased in comparison those of the healthy controls (P = 0.0236 and P = 0.0002, respectively).

conclusionThese findings suggest the role of BATF and CD112 not only as a role in T cell exhaustion, but in effector differentiation program in CLL, which warrants further studies in future.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellBasic-Leucine Zipper Transcription FactorsCase-Control StudiesGene Expression RegulationHumansLeukocytes, MononuclearNectinsPolymerase Chain ReactionBasic-Leucine Zipper Transcription FactorsBATF protein, humanNectinsBATFCD112Chronic Lymphocytic LeukemiaT-cell exhaustion

Identifiers

PMID37378949
PMCPMC10505859
OpenAlexW4382343663

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.