Evidence map›Paper›PMID 37378922›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia.

Salah Aref, Ahmed El Tantawy, Enas Gouda, Mohamed Ayed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Salah ArefHematology Unit, Department of Clinical Pathology, Mansoura University, Egypt.ORCID 0000-0002-4822-5204
Ahmed El TantawyOncology Unit, Mansoura University Oncology Center, Mansoura University, Egypt.
Enas GoudaHematology Unit, Department of Clinical Pathology, Mansoura University, Egypt.
Mohamed AyedHematology Unit, Department of Clinical Pathology, Mansoura University, Egypt.
Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundlittle is known regarding the prognostic value of soluble CD200 (sCD200)in  chronic lymphocytic leukemia patients. Therefore, the objective of our study is  to address the prognostic value of sCD200 antigen concentration on  CLL patients outcome.

methodsDetermination of  serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis  before start of therapy beside 21 healthy controls.

resultssCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls.  High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%.

conclusionDetermination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellEnzyme-Linked Immunosorbent AssayHumansPrognosisCLLoutcomePrognosis

Identifiers

PMID37378922
PMCPMC10505868
OpenAlexW4382344412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.