ArticleAnnals of biomedical engineering2023
Comparison of Immersed Boundary Simulations of Heart Valve Hemodynamics Against In Vitro 4D Flow MRI Data.
Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Simulations predict improved valve performance without direct leaflet intervention after neonatal truncus arteriosus repair.The Journal of thoracic and cardiovascular surgery · 2026Article
- In silico modelling of aortic annuloplasty: hemodynamic assessment through in vitro experiments and in vivo MRI.Computer methods and programs in biomedicine · 2026Article
- Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- A numerical framework for preprocedural prosthetic valve positioning and hemodynamic evaluation.Biomechanics and modeling in mechanobiology · 2025Article
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- Computational construction and design optimization of a novel tri-tube heart valve.Biomechanics and modeling in mechanobiology · 2025Article
- Simulation-based design of bicuspidization of the aortic valve.The Journal of thoracic and cardiovascular surgery · 2024Article
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.Biology · 2023Review
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Validation of the Reduced Unified Continuum Formulation Against In Vitro 4D-Flow MRI.Annals of biomedical engineering · 2023Article
- Controlled Comparison of Simulated Hemodynamics Across Tricuspid and Bicuspid Aortic Valves.Annals of biomedical engineering · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Direct comparison of FSI simulations around heart valves against experimental data is challenging, however, due to the difficulty of performing robust and effective simulations, the complications of modeling a specific physical experiment, and the need to acquire experimental data that is directly comparable to simulation data. Such comparators are a necessary precursor for further formal validation studies of FSI simulations involving heart valves. In this work, we performed physical experiments of flow through a pulmonary valve in an in vitro pulse duplicator, and measured the corresponding velocity field using 4D flow MRI (4-dimensional flow magnetic resonance imaging). We constructed a computer model of this pulmonary artery setup, including modeling valve geometry and material properties via a technique called design-based elasticity, and simulated flow through it with the IB method. The simulated flow fields showed excellent qualitative agreement with experiments, excellent agreement on integral metrics, and reasonable relative error in the entire flow domain and on slices of interest. These results illustrate how to construct a computational model of a physical experiment for use as a comparator.
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Registered trials
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