SynthesisOdontology2023
Postoperative pain after root canal filling with bioceramic sealers: a systematic review and meta-analysis of randomized clinical trials.
Synthesis in Odontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Effect of disinfection and tissue repair with chloramphenicol-tetracycline-ZOE paste on pulp therapy of primary teeth: a systematic review.Clinical oral investigations · 2025Pooled it
- Pooled it
- A systematic review and meta-analysis on the effects of phototherapy on postoperative pain in conventional endodontic reintervention.Clinical oral investigations · 2024Pooled it
- The effect of three different root canal filling materials on postoperative pain in teeth with irreversible pulpitis: a randomized clinical trial.BMC oral health · 2026Trial
- Effect of calcium silicate and epoxy resin-based sealers on postoperative pain: a randomized clinical trial.BMC oral health · 2026Trial
- The effect of different obturation techniques on post-obturation pain and sealer extrusion in single-visit root canal treatment: a prospective clinical randomized study.Clinical oral investigations · 2025Trial
- Clinical outcomes of nonsurgical root canal treatment using C-root SP combined with different obturation techniques in older patients: a randomized controlled clinical trial.BMC oral health · 2025Trial
- Postobturation Pain of three Novel Calcium Silicate-based sealers with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis: prospective clinical trial.BMC oral health · 2024Trial
- Bioceramic versus conventional endodontic sealers: An umbrella review.Journal of conservative dentistry and endodontics · 2026Review
- Post-Operative Pain After Endodontic Instrumentation, Irrigation and Obturation: An Umbrella Review of Systematic Reviews Published from 2016 to 2025.Journal of clinical medicine · 2026Review
- Silicone vs. Silicon/Silica in Intraoral Healing: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Adverse tissue reaction to a next-generation bioceramic sealer: a structured literature review and case report.Frontiers in dental medicine · 2026Review
- Periapical Lesion Healing After Retreatment and Root Canal Filling with a Bioceramic-Based Sealer: A Randomized Clinical Study with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- Randomized Trial of Bioceramic Apical Barrier Methods in Necrotic Immature Incisors: Effects on Pain, Extrusion, and Procedure Duration.Children (Basel, Switzerland) · 2025Article
- Randomised Clinical Trial: Effect of AH Plus and Neosealer Flo on Postoperative Pain and Healing of Periapical Lesions.Bioengineering (Basel, Switzerland) · 2025Article
- Comparative evaluation of postoperative pain and healing following root canal obturation with calcium silicate and bioactive glass-based sealers to epoxy resin-based sealers: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2025Article
- Post-operative pain after root canal filling with two different obturation techniques: A prospective study.Journal of clinical and experimental dentistry · 2024Article
- A three-dimensional cell culture approach to investigate cytotoxic effects and production of inflammatory mediators by epoxy resin-based and calcium silicate-based endodontic sealer.Clinical oral investigations · 2024Article
- Clinical and radiographic success of single-cone bioceramic obturation versus traditional techniques: a systematic review and meta-analysis of randomized controlled trials.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this systematic review and meta-analysis (SRM) was to assess postoperative pain (PP) after endodontic treatment with bioceramic root canal sealer compared to AH Plus® sealer. This SRM was carried out in accordance with the items on the PRISMA 2020 checklist and Cochrane guidelines and registered in PROSPERO (CRD42021259283). Only randomized clinical trials (RCTs) were included. Meta-analysis was conducted using R software, the standardized means difference (SMD) measure of effect was calculated for quantitative variables, and the odds ratio (OR) for binary variables. The Cochrane tool (RoB 2.0) was used to assess the risk of bias, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to assess the quality of evidence. Qualitative and quantitative analysis included 18 and 17 studies, respectively. For quantitative variables, the bioceramic root canal sealer presented less occurrence of postoperative pain than the AH Plus® sealer in 24 h (SMD - 0.17 [- 0.34; - 0.01], p = 0.0340). For binary variables, there was no difference observed between the sealers evaluated, except for sealer extrusion where the bioceramic group had lower post-filling material extrusion (OR 0.52 [0.32; 0.84], p = 0.007). Regarding the risk of bias analysis, low risk was observed for most domains, except allocation that was considered unclear, while the certainty of evidence ranged from moderate to low. The results showed that bioceramics sealers reduced postoperative endodontic pain only after 24 h and showed less sealer extrusion compared to the AH Plus® sealer. However, more robust and standardized clinical trials are needed to confirm the results with less heterogeneity and higher quality of evidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.