ArticleDrugs & aging2023
Association of Potentially Inappropriate Medication Classes with Mortality Risk Among Older Adults Initiating Hemodialysis.
Article in Drugs & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Drug Burden Index and Its Association With Functional Outcomes in Patients Receiving Hemodialysis.Kidney medicine · 2026Article
- Development of a nomogram for identifying prevalent medication discrepancy in maintenance hemodialysis patients: a multicenter cross-sectional study.Frontiers in medicine · 2026Article
- Medication Mindfulness: Implementation and Evaluation of a Single-Site, 6-Month Deprescribing Intervention for Patients on Hemodialysis.Kidney360 · 2025Article
- Medication review interventions for adults living with advanced chronic kidney disease: A scoping review.British journal of clinical pharmacology · 2025Article
- Sleep Patterns, Symptoms, and Mortality in Hemodialysis: A Prospective Cohort Study.Kidney medicine · 2025Article
- Association of Coprescribing of Gabapentinoid and Other Psychoactive Medications With Altered Mental Status and Falls in Adults Receiving Dialysis.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Observational
- Obesogenic Medication Use in End-Stage Kidney Disease and Association With Transplant Listing.Clinical transplantation · 2024Article
- Medication Deprescribing in Patients Receiving Hemodialysis: A Prospective Controlled Quality Improvement Study.Kidney medicine · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectiveOlder adults initiating dialysis have a high risk of mortality and that risk may be related to potentially inappropriate medications (PIMs). Our objective was to identify and validate mortality risk associated with American Geriatrics Society Beers Criteria PIM classes and concomitant PIM use.
methodsWe used US Renal Data System data to establish a cohort of adults aged ≥ 65 years initiating dialysis (2013-2014) and had no PIM prescriptions in the 6 months prior to dialysis initiation. In a development cohort (40% sample), adjusted Cox proportional hazards models were performed to determine which of 30 PIM classes were associated with mortality (or "high-risk" PIMs). Adjusted Cox models were performed to assess the association of the number of "high-risk" PIM fills/month with mortality. All models were repeated in the validation cohort (60% sample).
resultsIn the development cohort (n = 15,570), only 13 of 30 PIM classes were associated with a higher mortality risk. Compared with those with no "high-risk" PIM fills/month, patients having one "high-risk" PIM fill/month had a 1.29-fold (95% confidence interval 1.21-1.38) increased risk of death; those with two or more "high-risk" PIM fills/month had a 1.40-fold (95% confidence interval 1.24-1.58) increased risk. These findings were similar in the validation cohort (n = 23,569).
conclusionsOnly a minority of Beers Criteria PIM classes may be associated with mortality in the older dialysis population; however, mortality risk increases with concomitant use of "high-risk" PIMs. Additional studies are needed to confirm these associations and their underlying mechanisms.
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