Evidence map›Paper›PMID 37378777›Full record

ArticleAdvances in experimental medicine and biology2023

Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-Term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study.

Mojtaba Shafiekhani, Mahtabalsadat Mirjalili, Siavash Gholami, Pooya Vatankhah, Jamshid Roozbeh, Goli Mehrdad, Elham Haem, Zahra Zare, Seyed Soroush Jalali, Mehdi Golshan and 10 more

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Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Mojtaba ShafiekhaniShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahtabalsadat MirjaliliDepartment of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Siavash GholamiShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Pooya VatankhahShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Jamshid RoozbehShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Goli MehrdadShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Elham HaemDepartment of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra ZareShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Soroush JalaliDepartment of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mehdi GolshanShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Saman NikeghbalianShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Parisa ChamanparaDepartment of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza ShamsaeefarShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohsen MoghadamiDepartment of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamed NikoupourShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Ali MalekhosseiniShiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mojtaba SohrevardiDepartment of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Tannaz JamialahmadiSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirhossein SahebkarApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Bita GeramizadehShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRSina Hospital · IRMashhad University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral immune response with short-term clinical outcomes in solid organ transplant recipients vaccinated with SARS-CoV-2 vaccine (BBIBP-CorV; Sinopharm).MethodsThis prospective cohort was conducted from March to December 2021 in Abu Ali Sina hospital, Iran. All transplant recipients, older than 18 years were recruited. The patients received two doses of Sinopharm vaccine 4 weeks apart. Immunogenicity was evaluated through assessment of antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 after the first and second dose of vaccine. The patients were followed up for 6 months after vaccination.ResultsOut of 921 transplant patients, 115 (12.5%) and 239 (26%) had acceptable anti S-RBD immunoglobulin G (IgG) levels after the first and second dose, respectively. Eighty patients (8.68%) got infected with COVID-19 which led to 45 (4.9%) of patients being hospitalized. None of the patients died during follow-up period. Twenty-four (10.9%) liver transplant recipients developed liver enzyme elevation, and increased serum creatinine was observed in 86 (13.5%) kidney transplant patients. Two patients experienced biopsy-proven rejection without any graft loss.ConclusionOur study revealed that humoral response rate of solid organ transplant recipients to Sinopharm vaccine was low.

Indexed as

COVID-19Kidney TransplantationAntibodies, ViralCOVID-19 VaccinesHumansProspective StudiesSARS-CoV-2Transplant RecipientsVaccines, InactivatedAntibodies, ViralBIBP COVID-19 vaccineCOVID-19 VaccinesVaccines, InactivatedCOVID-19Humoral responseKidney transplantLiver transplantSinopharmVaccination

Identifiers

PMID37378777
OpenAlexW4382344152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.