Evidence map›Paper›PMID 37378737›Full record

Trial reportAnnals of nuclear medicine2023

Assessment of anti-GAD65-associated cerebellar ataxia with

Mohammad S Sadaghiani, Samantha Roman, Yujie Wang, Steven P Rowe, Jeffery P Leal, Scott D Newsome, Lilja B Solnes

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of nuclear medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohammad S SadaghianiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD, 21287, USA.
Samantha RomanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.
Yujie WangDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.
Steven P RoweDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD, 21287, USA.
Jeffery P LealDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD, 21287, USA.
Scott D NewsomeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.
Lilja B SolnesDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD, 21287, USA. lsolnes1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

National Institute of Biomedical imaging and Bioengineering of the National Institutes of Health T32EB006351
6 · The paper itself

Abstract

objectiveAnti-glutamic acid decarboxylase 65 (anti-GAD65)-associated neurological disorders include two major phenotypes, namely Stiff person syndrome (SPS) and cerebellar ataxia (CA). Considering the potential for better outcomes with prompt immunotherapy, early detection of CA is crucial. Hence, a non-invasive imaging biomarker to detect CA with high specificity is desired. Herein, we evaluated brain 2-deoxy-2-[

methodsThis study was based on STARD 2015 guidelines: thirty patients with anti-GAD65-associated neurological disorders, 11 of whom with CA were studied. Five test sets were created after patients were randomly sorted and divided into 5 equal folds. Each iteration included 24 patients for ROC analysis and 6 patients reserved for testing. The Z scores of left cerebellum, vermis, right cerebellum, and the average of the three regions were used in ROC analysis to determine areas with significant area under the curve (AUC). The cut-off values with high specificity were determined among the 24 patients in each iteration and tested against the reserved 6 patients.

resultsLeft cerebellum and average of the three regions showed significant AUC above 0.5 in all iterations with left cerebellum being the highest AUC in 4 iterations. Testing the cut-off values of the left cerebellum against the reserved 6 patients in each iteration showed 100% specificity with sensitivities ranging from 0 to 75%.

conclusionsCerebellar

Indexed as

Cerebellar AtaxiaFluorodeoxyglucose F18CerebellumGlucoseHumansPositron-Emission TomographyROC CurveFluorodeoxyglucose F18Glucose2-Deoxy-2-[18F]fluoro-D-glucoseCerebellar ataxiaFluorodeoxyglucoseGAD65Glutamic acid decarboxylase 65Positron emission tomographyStiff person syndrome

Identifiers

PMID37378737
OpenAlexW4382344686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.