Evidence map›Paper›PMID 37378710›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2023

Synthesis, characterisation, and solution behaviour of Ag(I) bis(phenanthroline-oxazine) complexes and the evaluation of their biological activity against the pathogenic yeast Candida albicans.

Clara Evans, Muhib Ahmed, Darren F Beirne, Malachy McCann, Kevin Kavanagh, Michael Devereux, Denise Rooney, Frances Heaney

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clara EvansDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland.
Muhib AhmedDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland.
Darren F BeirneDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland.
Malachy McCannDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland.
Kevin KavanaghKathleen Lonsdale Institute for Human Health Research, Maynooth University, Co. Kildare, Maynooth, Ireland.
Michael DevereuxThe Centre for Biomimetic and Therapeutic Research, Focas Research Institute, Technological University Dublin, Dublin 8, Ireland.
Denise RooneyDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland. denise.rooney@mu.ie.ORCID 0000-0002-6313-4271
Frances HeaneyDepartment of Chemistry, Maynooth University, Co. Kildare, Maynooth, Ireland.
National University of Ireland, Maynooth · IETechnological University Dublin · IE

Funding

Irish Research Council Government of Ireland Postgraduate Award GOIPG/2020/1448
6 · The paper itself

Abstract

Three Ag(I) bis(phenanthroline-oxazine) complexes with varying lipophilicity were synthesised and characterised. The solution stoichiometry of 1:2 Ag(I):ligand was determined for each complex by the continuous variation Job's plot method using NMR spectroscopy. NMR studies were also carried out to investigate the fluxional behaviour of the Ag(I) complexes in solution. The biological activity of the silver(I) complexes and the corresponding ligands towards a clinical strain of Candida albicans MEN was studied using broth microdilution assays. Testing showed the choice of media and the duration of incubation were key determinants of the inhibitory behaviour towards Candida albicans, however, the difference between freshly prepared and pre-prepared solutions was insignificant in minimal media. The activity of the metal-free ligands correlated with the length of the alkyl chain. In minimal media, the methyl ester phenanthroline-oxazine ligand was effective only at 60 μM, limiting growth to 67% of the control, while a 60 μM dose of the propyl ester analogue limited fungal growth at < 20% of the control. MIC

Indexed as

Candida albicansPhenanthrolinesEstersHumansLigandsOxazinesSilverEstersLigandsOxazinesPhenanthrolinesSilverAntifungal activityCulture mediaDynamic solution behaviourIncubation timePhenanthrolineSilver(I) complexes

Identifiers

PMID37378710
PMCPMC10684714
OpenAlexW4382344081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.