Evidence map›Paper›PMID 37378450›Full record

ArticleLupus2023

Cost-related prescription non-adherence and patient-reported outcomes in systemic lupus erythematosus: The Michigan Lupus Epidemiology & Surveillance program.

Deeba Minhas, Wendy Marder, Afton L Hassett, Suzanna M Zick, Caroline Gordon, Sioban D Harlow, Lu Wang, Kamil E Barbour, Charles G Helmick, W Joseph McCune and 1 more

Open access · greenAbstract read
In one paragraph

Article in Lupus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Deeba MinhasDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Wendy MarderDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7963-4206
Afton L HassettDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Suzanna M ZickDepartment of Family Medicine, University of Michigan, Ann Arbor, MI, USA.
Caroline GordonRheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1244-6443
Sioban D HarlowDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Lu WangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Kamil E BarbourCenters for Disease Control and Prevention, Atlanta, GA, USA.
Charles G HelmickCenters for Disease Control and Prevention, Atlanta, GA, USA.
W Joseph McCuneDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Emily C SomersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5234-3978
University of Michigan · USCenters for Disease Control and Prevention · USUniversity of Birmingham · GB

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STUART A BATTERMAN · 2011 to 2026
$21.3M
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal CohortU01DP003250 · DP · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOMERS, EMILY CATHERINE · 2012 to 2015
$3.0M
Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & BiobankU01DP006265 · DP · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOMERS, EMILY CATHERINE · 2016 to 2018
$2.9M
Michigan Lupus Epidemiology and Surveillance (MILES) Program Longitudinal Cohort & BiobankU01DP006489 · DP · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOMERS, EMILY CATHERINE · 2019 to 2021
$2.6M
Immune dysfunction associated with early life heavy metal exposureK01ES019909 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOMERS, EMILY CATHERINE · 2011 to 2015
$670k
NCATS NIH HHS UL1 TR002240NCATS NIH HHS UM1 TR004404NCCDPHP CDC HHS U01 DP003250NCCDPHP CDC HHS U01 DP006265NCCDPHP CDC HHS U01 DP006489NIEHS NIH HHS K01 ES019909NIEHS NIH HHS P30 ES017885
6 · The paper itself

Abstract

objectivesMedication access and adherence play key roles in determining patient outcomes. We investigated whether cost-related non-adherence (CRNA) to prescription medications was associated with worse patient-reported outcomes in a population-based systemic lupus erythematosus (SLE) cohort.

methodsSociodemographic and prescription data were collected by structured interviews in 2014-2015 from patients meeting SLE criteria in the established Michigan Lupus Epidemiology & Surveillance (MILES) Cohort. We examined the associations between CRNA and potential confounders such as sociodemographics and health insurance coverage, and outcome measures of SLE activity and damage using multivariable linear regression.

results462 SLE participants completed the study visit: 430 (93.1%) female, 208 (45%) Black, and mean age 53.3 years. 100 (21.6%) participants with SLE reported CRNA in the preceding 12 months. After adjusting for covariates, CRNA was associated with both higher levels of current SLE disease activity [SLAQ: β coeff 2.7 (95% CI 1.3, 4.1),

conclusionPatients with SLE who reported CRNA in the previous 12 months had significantly worse self-reported current disease activity and damage scores compared to those not reporting CRNA. Raising awareness and addressing barriers or concerns related to financial implications and accessibility issues in care plans may help to improve these outcomes.

Indexed as

Lupus Erythematosus, SystemicFemaleHumansMaleMichiganMiddle AgedPatient Reported Outcome MeasuresPrescriptionsRNA, ComplementaryRNA, Complementaryepidemiologyhealth services researchLupusnon-adherencepatient-reported outcomesprescriptions

Identifiers

PMID37378450
PMCPMC10585710
OpenAlexW4382343957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.