ArticleIranian journal of veterinary research2023
An investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattle.
Article in Iranian journal of veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Bovine Ocular Squamous Cell Carcinoma-A Descriptive Epidemiological Survey in the Azores, Portugal.Veterinary sciences · 2026Article
- Ocular squamous cell carcinoma in cattle: clinicopathological and prognostic considerations.Brazilian journal of veterinary medicine · 2026Article
- Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report.Veterinary medicine and science · 2025Article
- Investigation of DNA Damage and Apoptosis in Bovine Ocular Squamous Cell Carcinoma.Veterinary medicine and science · 2025Article
- Molecular Analysis and Bioinformatics Assessment of Full-Length L1 Gene of Bovine Papillomavirus Type-1 as a Potential DNA Vaccine Study.Veterinary medicine international · 2025Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ocular squamous cell carcinomas (OSCCs) in cattle has been studied for many years, but no definite etiology has been established. Squamous cell carcinomas (SCCs) may occur in different body parts of cattle. Depending on the location, it can cause an economic loss of varying degrees. Aims: The aim of this study was to investigate the causes of OSCCs in the eye region of cattle. Results: Macroscopically masses were nodular or cauliflower-like and fragile and had hemorrhagic surfaces. Considering the keratin pearls, tumoral islands, and squamous differentiation, 20 out of 60 cases were classified as well, 20 as moderately, and 20 as poorly-differentiated OSCCs. 47 of the 60 cases were BPV positive using immunohistochemical methods. However, BPV nucleic acid was detected in only two cases with PCR. Only one of the cases could be sequenced. After phylogenetic analysis, virus strain was identified as BPV-1. Conclusion: Our results indicated that papillomaviruses can contribute to the development of OSCCs, in both precursor lesions and also advanced stage OSCCs. We found that BPV-1 has a possible causative role; however, more studies are needed to investigate the role of other viral agents and their interaction with secondary factors.
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