Evidence map›Paper›PMID 37378147›Full record

ArticleCureus2023

COVID-19 in Pediatric Patients: A Study Based on Biomarker Levels.

Walaa Mohammedsaeed, Fahad Alsehli, Lutfi Alfarsi, Ameen Bakhsh, Mansour Alzahrani, Maram Almarwani, Yousef Alharbi

Abstract read
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Walaa MohammedsaeedDiabetes and Endocrinology, Clinical Biochemistry, Taibah University, Madinah, SAU.
Fahad AlsehliPathology, King Salman Medical City, Madinah, SAU.
Lutfi AlfarsiPathology, Medina Regional Laboratory, Madinah, SAU.
Ameen BakhshLaboratory, Maternity and Children Hospital, Madinah, SAU.
Mansour AlzahraniLaboratory, Poison control and Forensic Chemistry Center, Madinah, SAU.
Maram AlmarwaniLaboratory, Maternity and Children Hospital, Madinah, SAU.
Yousef AlharbiLaboratory, Maternity and Children Hospital, Madinah, SAU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected people of all ages, but limited data are available on children with mild and severe coronavirus disease 2019 (COVID-19).

methodsClinical characteristics, inflammation, and other biochemical biomarkers have been described, but information is scarce in asymptomatic and mild cases. Laboratory investigations were performed with pediatric patients (n=70) for liver function and kidney function, along with C-reactive protein (CRP).

resultsMild clinical characteristics and symptoms were observed in pediatric patients. Even in moderate cases of COVID-19, elevated levels of biomarkers indicate altered liver and kidney function in children. The levels of liver enzymes, bilirubin, creatinine, and CRP varied significantly between the three classes, particularly between asymptomatic and moderate cases. Liver enzymes, bilirubin, and creatinine levels in moderate COVID-19 pediatric cases were twice as elevated as in asymptomatic cases. Liver enzymes and CRP levels were moderately elevated.

conclusionMonitoring blood biomarkers consistently can assist in the accurate identification of infection in young patients as well as in the prevention of its spread and the administration of appropriate treatment.

Indexed as

biochemical markersinfectionpediatric patientssars-cov-2severity of covid-19

Identifiers

PMID37378147
PMCPMC10291959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.