Evidence map›Paper›PMID 37378084›Full record

ArticleCritical care explorations2023

RNA Sequencing Analysis of CD4

Michael J Ripple, Min Huang, Susan T Stephenson, Ahmad F Mohammad, Mallory Tidwell, Anne M Fitzpatrick, Rishikesan Kamaleswaran, Jocelyn R Grunwell

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael J RippleDivision of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, GA.
Min HuangDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
Susan T StephensonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Ahmad F MohammadDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Mallory TidwellDivision of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, GA.
Anne M FitzpatrickDivision of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, GA.
Rishikesan KamaleswaranDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Jocelyn R GrunwellDivision of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, GA.
Emory University · USGeorgia Institute of Technology · US

Funding

Mentored patient-oriented research in preschool wheezing disordersK24NR018866 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO · 2020 to 2024
$625k
NINR NIH HHS K24 NR018866
6 · The paper itself

Abstract

CD4

objectivesTo identify differentially expressed genes and networks using a novel transcriptomic reporter assay with donor CD4

designIn vitro pilot study.

settingLaboratory-based study using human airway fluid samples admitted to a 36-bed university-affiliated pediatric intensive care unit. PATIENTS/SUBJECTS: Seven children with severe PARDS, nine children with mild PARDS, and four intubated children without lung injury as controls.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe performed bulk RNA sequencing using a transcriptomic reporter assay of CD4

conclusionsWe identified gene networks important to the PARDS airway immune response using bulk RNA sequencing from a novel CD4

Indexed as

pediatric acute respiratory distress syndromepediatric intensive careribonucleic acid sequencingT cellstracheal aspiratetranscriptomics

Identifiers

PMID37378084
PMCPMC10292738
OpenAlexW4381929826

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.