Evidence map›Paper›PMID 37377691›Full record

ArticleFrontiers in allergy2023

Deletion of Miro1 in airway club cells potentiates allergic asthma phenotypes.

Sierra Bruno, Amelia Lamberty, Margaret McCoy, Zoe Mark, Nirav Daphtary, Minara Aliyeva, Kelly Butnor, Matthew E Poynter, Vikas Anathy, Brian Cunniff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sierra Bruno *Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Amelia Lamberty *Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Margaret McCoyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Zoe MarkDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Nirav DaphtaryDepartment of Medicine, University of Vermont, Burlington, VT, United States.
Minara AliyevaDepartment of Medicine, University of Vermont, Burlington, VT, United States.
Kelly ButnorDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Matthew E PoynterDepartment of Medicine, University of Vermont, Burlington, VT, United States.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
Brian CunniffDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, United States.
University of Vermont · US

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial FunctionR01HL133920 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, POYNTER, MATTHEW E · 2016 to 2020
$3.9M
Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
Endoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5M
Ketone Body Supplementation in Obese AsthmaR01HL142081 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2018 to 2021
$1.8M
Unfolded protein response in Influenza virus infection and inflammationR01HL141364 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2019 to 2022
$1.6M
Nikon A1R-ER Confocal Microscope for the Microscopy Imaging CenterS10OD025030 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TAATJES, DOUGLAS J. · 2018 to 2018
$557k
NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01 HL133920NHLBI NIH HHS R01 HL136917NHLBI NIH HHS R01 HL141364NHLBI NIH HHS R01 HL142081NHLBI NIH HHS T32 HL076122NIH HHS S10 OD025030
6 · The paper itself

Abstract

Mitochondria are multifaceted organelles necessary for numerous cellular signaling and regulatory processes. Mitochondria are dynamic organelles, trafficked and anchored to subcellular sites depending upon the cellular and tissue requirements. Precise localization of mitochondria to apical and basolateral membranes in lung epithelial cells is important for key mitochondrial processes. Miro1 is an outer mitochondrial membrane GTPase that associates with adapter proteins and microtubule motors to promote intracellular movement of mitochondria. We show that deletion of

Indexed as

asthmahouse dust mite (HDM)inflammationMiro1mitochondria

Identifiers

PMID37377691
PMCPMC10291198
OpenAlexW4380264627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.