Evidence map›Paper›PMID 37377467›Full record

ArticleFrontiers in psychiatry2023

Sleep spindles across youth affected by schizophrenia or anti-

Maria E Dimitriades, Andjela Markovic, Silvano R Gefferie, Ashura Buckley, David I Driver, Judith L Rapoport, Margherita Nosadini, Kevin Rostasy, Stefano Sartori, Agnese Suppiej and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 5 countries.

Maria E DimitriadesChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Andjela MarkovicDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Silvano R GefferieStichting Epilepsie Instellingen Nederland, Heemstede, Netherlands.
Ashura BuckleyPediatrics and Neurodevelopmental Neuroscience, National Institute of Mental Health, Bethesda, MD, United States.
David I DriverChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.
Judith L RapoportChild Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, United States.
Margherita NosadiniPaediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.
Kevin RostasyDepartment of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln, Germany.
Stefano SartoriPaediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.
Agnese SuppiejDepartment of Medical Sciences, Pediatric Section, University of Ferrara, Ferrara, Italy.
Salome KurthDepartment of Psychology, University of Fribourg, Fribourg, Switzerland.
Maurizia FransciniDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Reto HuberChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Leila TarokhUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Bigna K BölsterliChild Development Center, University Children's Hospital Zurich, Zurich, Switzerland.
Miriam GerstenbergChildren's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
National Institute of Mental Health · USUniversity Children's Hospital Zurich · CHCittà della Speranza Foundation · ITUniversity Hospital of Zurich · CHUniversity of Zurich · CHLeiden University Medical Center · NLUniversity of Bern · CHUniversity of Ferrara · ITUniversity of Fribourg · CHWitten/Herdecke University · DE

Funding

Childhood Onset SchizophreniaZIAMH002581 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2017
$25.5M
Intramural NIH HHS ZIA MH002581
6 · The paper itself

Abstract

Background: Sleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. Altered glutamatergic neurotransmission within this network via a hypofunction of the Methods: Sleep EEG data of patients with COS ( Results: Central sleep spindle density, maximum amplitude, and sigma power were reduced when comparing all patients with psychosis to all HC. Between patient group comparisons showed no differences in central spindle density but lower central maximum amplitude and sigma power in patients with COS compared to patients with EOS or NMDARE. Assessing the topography of spindle density, it was significantly reduced over 15/17 electrodes in COS, 3/17 in EOS, and 0/5 in NMDARE compared to HC. In the pooled sample of COS and EOS, a longer duration of illness was associated with lower central sigma power. Conclusions: Patients with COS demonstrated more pronounced impairments of sleep spindles compared to patients with EOS and NMDARE. In this sample, there is no strong evidence that changes in NMDAR activity are related to spindle deficits.

Indexed as

anti-NMDAR encephalitispsychosisschizophreniasleep EEGsleep spindlesthalamocortical network

Identifiers

PMID37377467
PMCPMC10292628
OpenAlexW4379648749

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.