Evidence map›Paper›PMID 37377254›Full record

Trial reportActa obstetricia et gynecologica Scandinavica2023

Meconium-stained amniotic fluid and neonatal morbidity in nulliparous patients with prolonged pregnancy.

Isabelle Attali, Diane Korb, Elie Azria, Jacques Lepercq, François Goffinet, Thomas Schmitz, Groupe de Recherche en Obstétrique et Gynécologie (GROG)

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06849037 (and Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Who Will be Treated With Prophylactic Antibiotics Zinacef vs. Placebo), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06849037 narecruitingnot on this mapstarted 2025, after this paper: background citation

and Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Who Will be Treated With Prophylactic Antibiotics Zinacef vs. Placebo

TypeinterventionalSponsorWestern Galilee Hospital-NahariyaRan2025 to 2029Enrolled182ConditionsMeconium-stained Amniotic Fluid, ChorioamnionitisArmszinacef tretment, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Isabelle AttaliDepartment of Obstetrics and Gynecology, Robert Debré Hospital, AP-HP, Université Paris Cité, Paris, France.
Diane KorbDepartment of Obstetrics and Gynecology, Robert Debré Hospital, AP-HP, Université Paris Cité, Paris, France.ORCID 0000-0002-3074-8269
Elie AzriaCRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, INSERM, INRA, Université de Paris, Paris, France.
Jacques LepercqAssistance Publique-Hôpitaux de Paris, Maternité Port-Royal, Paris, France.ORCID 0000-0002-0574-3749
François GoffinetCRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, INSERM, INRA, Université de Paris, Paris, France.
Thomas SchmitzDepartment of Obstetrics and Gynecology, Robert Debré Hospital, AP-HP, Université Paris Cité, Paris, France.
Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOur objective was to study the strength of the association between meconium-stained amniotic fluid and severe morbidity among neonates of nulliparas with prolonged pregnancies. MATERIAL AND

methodsThis was a secondary analysis of the NOCETER randomized trial that took place between 2009 and 2012 in which 11 French maternity units included 1373 nulliparas at 41

resultsThis study included 1274 patients: 803 (63%) in the group with normal amniotic fluid, 196 (15.4%) in the thin amniotic fluid group, and 275 (21.6%) in the thick amniotic fluid group. The neonates of patients with thick amniotic fluid had higher rates of neonatal morbidity than those of patients with normal amniotic fluid (7.3% vs. 2.2%; p < 0.001; adjusted relative risk [aRR] 3.3, 95% confidence interval [CI] 1.7-6.3), but those of patients with thin amniotic fluid did not (3.1% vs. 2.2%; p = 0.50; aRR 1.0, 95% CI, 0.4-2.7).

conclusionsAmong nulliparas at 41

Indexed as

Amniotic FluidInfant, Newborn, DiseasesMeconiumMeconium Aspiration SyndromePregnancy, ProlongedFemaleHumansInfant, NewbornObstetric Labor ComplicationsPregnancyPregnancy Complicationsnulliparasprolonged pregnancysevere neonatal morbiditythick meconiumthin meconium

Identifiers

PMID37377254
PMCPMC10377997
OpenAlexW4382344377

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.