Evidence map›Paper›PMID 37377253›Full record

ArticleMemorias do Instituto Oswaldo Cruz2023

Insecticide resistance levels and associated mechanisms in three Aedes aegypti populations from Venezuela.

Yasmin Rubio-Palis, Nicole Dzuris, Christopher Sandi, Rita Lucrecia Vizcaino-Cabarrus, Claudia Corredor-Medina, Jesús Alberto González, Audrey E Lenhart

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Yasmin Rubio-PalisUniversidad de Carabobo, Instituto de Investigaciones Biomédicas, Maracay, Venezuela.ORCID http://orcid.org/0000-0003-0056-2540
Nicole DzurisUS Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, Entomology Branch, Atlanta, GA, USA.
Christopher SandiUS Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, Entomology Branch, Atlanta, GA, USA.
Rita Lucrecia Vizcaino-CabarrusUS Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, Entomology Branch, Atlanta, GA, USA.
Claudia Corredor-MedinaUS Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, Entomology Branch, Atlanta, GA, USA.
Jesús Alberto GonzálezMinisterio del Poder Popular para la Salud, Dirección General de Salud Ambiental, Dirección de Control de Vectores, Maracay, Venezuela.
Audrey E LenhartUS Centers for Disease Control and Prevention, Center for Global Health, Division of Parasitic Diseases and Malaria, Entomology Branch, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USMinisterio del Poder Popular para la Educación Universitaria, Ciencia y Tecnología · VEUniversity of Carabobo · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe massive use of insecticides in public health has exerted selective pressure resulting in the development of resistance in Aedes aegypti to different insecticides in Venezuela. Between 2010 and 2020, the only insecticides available for vector control were the organophosphates (Ops) fenitrothion and temephos which were focally applied.

objectivesTo determine the state of insecticide resistance and to identify the possible biochemical and molecular mechanisms involved in three populations of Ae. aegypti from Venezuela.

methodsCDC bottle bioassays were conducted on Ae. aegypti collected between October 2019 and February 2020 in two hyperendemic localities for dengue in Aragua State and in a malaria endemic area in Bolívar State. Insecticide resistance mechanisms were studied using biochemical assays and polymerase chain reaction (PCR) to detect kdr mutations.

findingsBioassays showed contrasting results among populations; Las Brisas was resistant to malathion, permethrin and deltamethrin, Urbanización 19 de Abril was resistant to permethrin and Nacupay to malathion. All populations showed significantly higher activity of mixed function oxidases and glutathione-S-transferases (GSTs) in comparison with the susceptible strain. The kdr mutations V410L, F1534C, and V1016I were detected in all populations, with F1534C at higher frequencies. MAIN

conclusionInsecticide resistance persists in three Ae. aegypti populations from Venezuela even in the relative absence of insecticide application.

Indexed as

AedesInsecticidesPyrethrinsAnimalsInsecticide ResistanceMalathionMosquito VectorsPermethrinVenezuelaInsecticidesMalathionPermethrinPyrethrins

Identifiers

PMID37377253
PMCPMC10292823
OpenAlexW4381805127

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.