Evidence map›Paper›PMID 37376818›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Multi-Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management.

Wenzhao Li, Yunru Yu, Rongkang Huang, Xiaocheng Wang, Puxiang Lai, Kai Chen, Luoran Shang, Yuanjin Zhao

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Wenzhao LiDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID 0000-0002-5976-0069
Yunru YuDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Rongkang HuangDepartment of General Surgery and Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, 510655, China.
Xiaocheng WangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Puxiang LaiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, SAR, 999077, China.
Kai ChenDepartment of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Luoran ShangOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.ORCID 0000-0001-7458-9100
Yuanjin ZhaoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.ORCID 0000-0001-9242-4000
Nanjing Drum Tower Hospital · CNHong Kong Polytechnic University · HKFudan University · CNSecond Military Medical University · CNSun Yat-sen University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2021B1515120054Nanjing Medical Science and Technique Development Foundation ZKX21019National Key Research and Development Program of China 2022YFB4700100National Natural Science Foundation of China 52073060National Natural Science Foundation of China 61927805National Natural Science Foundation of China T2225003Shenzhen Fundamental Research Program JCYJ20190813152616459Shenzhen Fundamental Research Program JCYJ20210324133214038
6 · The paper itself

Abstract

Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most of them still lack satisfactory controllability and comprehensive functionality. Herein, inspired by multiple creatures, including octopuses and snails, a novel muti-functional hydrogel patch is presented with controlled adhesion, antibacterial, drug release features, and multiple monitoring functions for intelligent wound healing management. The patch with micro suction-cup actuator array and a tensile backing layer is composed of tannin grafted gelatin, Ag-tannin nanoparticles, polyacrylamide (PAAm) and poly(N-isopropylacrylamide) (PNIPAm). In virtue of the photothermal gel-sol transition of tannin grafted gelatin and Ag-tannin nanoparticles, the patches exert a dual anti-microbial effect and temperature-sensitive snail mucus-like features. In addition, as the "suction-cups" consisting of thermal responsive PNIPAm can undergo a contract-relax transformation, the medical patches can adhere to the objects reversibly and responsively, and release their loaded vascular endothelial growth factor (VEGF) controllably for wound healing. More attractively, benefiting from their fatigue resistance, self-healing ability of the tensile double network hydrogel, and electrical conductivity of Ag-tannin nanoparticles, the proposed patches can report multiple wound physiology parameters sensitively and continuously. Thus, it is believed that this multi-bioinspired patch has immense potential for future wound healing management.

Indexed as

GelatinHydrogelsElectric ConductivityVascular Endothelial Growth Factor AWound HealingGelatinHydrogelsVascular Endothelial Growth Factor Aactuatorbio-inspiredflexible electronicshydrogelphoto-responsewound healing

Identifiers

PMID37376818
PMCPMC10477846
OpenAlexW4382344354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.