ArticleEpilepsia2023
Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- The Association of Neighborhood Disadvantage with Surgical Outcomes and Follow-up Adherence in Patients with Cleft Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- Disentangling deprivation: Differential associations of the area deprivation index- 3 factors with clinical, cognitive, and mood outcomes in epilepsy.Epilepsy & behavior : E&B · 2026Article
- General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy.Epilepsia open · 2025Article
- Juvenile Myoclonic Epilepsy Imaging Endophenotypes and Relationship With Cognition and Resting-State EEG.Human brain mapping · 2025Article
- Cognitive and brain health in juvenile myoclonic epilepsy: Role of social determinants of health.Epilepsia · 2025Article
- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- Characterizing white matter connectome abnormalities in patients with temporal lobe epilepsy using threshold-free network-based statistics.Brain and behavior · 2024Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSocial determinants of health, including the effects of neighborhood disadvantage, impact epilepsy prevalence, treatment, and outcomes. This study characterized the association between aberrant white matter connectivity in temporal lobe epilepsy (TLE) and disadvantage using a US census-based neighborhood disadvantage metric, the Area Deprivation Index (ADI), derived from measures of income, education, employment, and housing quality.
methodsParticipants including 74 TLE patients (47 male, mean age = 39.2 years) and 45 healthy controls (27 male, mean age = 31.9 years) from the Epilepsy Connectome Project were classified into ADI-defined low and high disadvantage groups. Graph theoretic metrics were applied to multishell connectome diffusion-weighted imaging (DWI) measurements to derive 162 × 162 structural connectivity matrices (SCMs). The SCMs were harmonized using neuroCombat to account for interscanner differences. Threshold-free network-based statistics were used for analysis, and findings were correlated with ADI quintile metrics. A decrease in cross-sectional area (CSA) indicates reduced white matter integrity.
resultsSex- and age-adjusted CSA in TLE groups was significantly reduced compared to controls regardless of disadvantage status, revealing discrete aberrant white matter tract connectivity abnormalities in addition to apparent differences in graph measures of connectivity and network-based statistics. When comparing broadly defined disadvantaged TLE groups, differences were at trend level. Sensitivity analyses of ADI quintile extremes revealed significantly lower CSA in the most compared to least disadvantaged TLE group. SIGNIFICANCE: Our findings demonstrate (1) the general impact of TLE on DWI connectome status is larger than the association with neighborhood disadvantage; however, (2) neighborhood disadvantage, indexed by ADI, revealed modest relationships with white matter structure and integrity on sensitivity analysis in TLE. Further studies are needed to explore this relationship and determine whether the white matter relationship with ADI is driven by social drift or environmental influences on brain development. Understanding the etiology and course of the disadvantage-brain integrity relationship may serve to inform care, management, and policy for patients.
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