Evidence map›Paper›PMID 37376610›Full record

ArticleViruses2023

Congenital SARS-CoV-2 Infection in Two Neonates with Confirmation by Viral Culture of the Placenta in One Case.

Joseph V Vayalumkal, Amuchou S Soraisham, Ayman Abou Mehrem, Anirban Ghosh, Jessica K E Dunn, Kevin Fonseca, Hong Zhou, Byron M Berenger, Elaine S Chan, Marie-Anne Brundler and 5 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Joseph V VayalumkalDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.
Amuchou S SoraishamDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.
Ayman Abou MehremDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0003-3805-949X
Anirban GhoshDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.
Jessica K E DunnDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.
Kevin FonsecaAlberta Public Health Laboratory, Alberta Precision Laboratories, Calgary, AB T2N 4W4, Canada.
Hong ZhouAlberta Public Health Laboratory, Alberta Precision Laboratories, Calgary, AB T2N 4W4, Canada.
Byron M BerengerAlberta Public Health Laboratory, Alberta Precision Laboratories, Calgary, AB T2N 4W4, Canada.
Elaine S ChanDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0001-5260-5798
Marie-Anne BrundlerDepartment of Pediatrics, Alberta Health Services, University of Calgary, Calgary, AB T2N 4N1, Canada.
Yi-Chan LinDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.ORCID 0000-0003-0867-220X
David H EvansDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.ORCID 0000-0001-5871-299X
Sharon RoussoDepartment of Pediatrics, Red Deer Regional Hospital, Red Deer, AB T4N 4E7, Canada.ORCID 0000-0002-8253-2590
Verena KuretDepartment of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 4N1, Canada.
John M ConlyDepartment of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
Alberta Health Services · CAUniversity of Calgary · CAUniversity of Alberta · CARed Deer Regional Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital infections with SARS-CoV-2 are uncommon. We describe two confirmed congenital SARS-CoV-2 infections using descriptive, epidemiologic and standard laboratory methods and in one case, viral culture. Clinical data were obtained from health records. Nasopharyngeal (NP) specimens, cord blood and placentas when available were tested by reverse transcriptase real-time PCR (RT-PCR). Electron microscopy and histopathological examination with immunostaining for SARS-CoV-2 was conducted on the placentas. For Case 1, placenta, umbilical cord, and cord blood were cultured for SARS-CoV-2 on Vero cells. This neonate was born at 30 weeks, 2 days gestation by vaginal delivery. RT-PCR tests were positive for SARS-CoV-2 from NP swabs and cord blood; NP swab from the mother and placental tissue were positive for SARS-CoV-2. Placental tissue yielded viral plaques with typical morphology for SARS-CoV-2 at 2.8 × 10

Indexed as

COVID-19Pregnancy Complications, InfectiousAnimalsChlorocebus aethiopsFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPlacentaPregnancySARS-CoV-2TrophoblastsVero CellscongenitalCOVID-19neonatalpregnancySARS-CoV-2transplacentalviral culture

Identifiers

PMID37376610
PMCPMC10301936
OpenAlexW4379054365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.