Evidence map›Paper›PMID 37376593›Full record

ArticleViruses2023

Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes.

Elena K Kokinos, Sergey A Tsymbal, Anastasia V Galochkina, Svetlana A Bezlepkina, Julia V Nikolaeva, Sofia O Vershinina, Anna A Shtro, Victor V Tatarskiy, Alexander A Shtil, Eugenia V Broude and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Elena K KokinosSCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia.
Sergey A TsymbalSCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia.ORCID 0000-0003-2230-6767
Anastasia V GalochkinaSmorodintsev Research Institute of Influenza, 15/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia.
Svetlana A BezlepkinaSCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia.ORCID 0009-0002-6592-1575
Julia V NikolaevaSmorodintsev Research Institute of Influenza, 15/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia.
Sofia O VershininaSCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia.
Anna A ShtroSmorodintsev Research Institute of Influenza, 15/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia.
Victor V TatarskiyInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilova Street, 119334 Moscow, Russia.ORCID 0000-0002-9080-5683
Alexander A ShtilBlokhin National Medical Research Center of Oncology, Kashirskoe Highway 24, 115478 Moscow, Russia.
Eugenia V BroudeDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, Sumter Street 715, Columbia, SC 29208, USA.
Igor B RoninsonDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, Sumter Street 715, Columbia, SC 29208, USA.ORCID 0000-0002-9211-1327
Marina DukhinovaSCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia.
ITMO University · RUResearch Institute of Influenza · RUUniversity of South Carolina Sumter · USInstitute of Gene Biology · RU

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
6 · The paper itself

Abstract

Hyperactivation of the immune system remains a dramatic, life-threatening complication of viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to counteract local and systemic outbreaks of cytokine storm and to prevent tissue damage remain limited. Cyclin-dependent kinases 8 and 19 (CDK8/19) potentiate transcriptional responses to the altered microenvironment, but CDK8/19 potential in immunoregulation is not fully understood. In the present study, we investigated how a selective CDK8/19 inhibitor, Senexin B, impacts the immunogenic profiles of monocytic cells stimulated using influenza virus H1N1 or bacterial lipopolysaccharides. Senexin B was able to prevent the induction of gene expression of proinflammatory cytokines in THP1 and U937 cell lines and in human peripheral blood-derived mononuclear cells. Moreover, Senexin B substantially reduced functional manifestations of inflammation, including clustering and chemokine-dependent migration of THP1 monocytes and human pulmonary fibroblasts (HPF).

Indexed as

Influenza A Virus, H1N1 SubtypeMonocytesCytokinesHumansLeukocytes, MononuclearU937 CellsCytokinesCDK8/19cytokinesinflammationinfluenza viruslipopolysaccharidemonocytes

Identifiers

PMID37376593
PMCPMC10305654
OpenAlexW4378904383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.