Evidence map›Paper›PMID 37376575›Full record

ArticleViruses2023

Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay.

Cynthia Vazquez, Luiz Carlos Junior Alcantara, Vagner Fonseca, Mauricio Lima, Joilson Xavier, Talita Adelino, Hegger Fritsch, Emerson Castro, Carla de Oliveira, Gabriel Schuab and 27 more

Abstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Cynthia VazquezLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Luiz Carlos Junior AlcantaraInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.
Vagner FonsecaOrganização Pan-Americana da Saúde, Organização Mundial da Saúde, Brasília 70-800400, SP, Brazil.
Mauricio LimaInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-0830-3909
Joilson XavierInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0003-3916-2018
Talita AdelinoLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, MG, Brazil.
Hegger FritschInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-1997-5786
Emerson CastroLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, MG, Brazil.ORCID 0000-0002-3210-7342
Carla de OliveiraLaboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Instituto Osawldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-0829-036X
Gabriel SchuabLaboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Instituto Osawldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil.
Alex Ranieri Jerônimo LimaButantan Institute, Center for Viral Surveillance and Serological Assessment (CeVIVAS), Sao Paulo 05507-000, SP, Brazil.
Shirley VillalbaLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Andrea Gomez de la FuenteLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Analia RojasLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Cesar CanteroLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.ORCID 0000-0001-5381-8461
Fatima FleitasLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Carolina AquinoLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Andrea OjedaDirección General de Vigilancia de la Salud, Asunción 40556, Paraguay.
Guillermo SequeraDirección General de Vigilancia de la Salud, Asunción 40556, Paraguay.ORCID 0000-0002-7707-1363
Juan ToralesLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Julio BarriosLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.ORCID 0000-0003-4120-4141
Maria Carolina EliasButantan Institute, Center for Viral Surveillance and Serological Assessment (CeVIVAS), Sao Paulo 05507-000, SP, Brazil.ORCID 0000-0002-0501-8280
Felipe C M IaniLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, MG, Brazil.ORCID 0000-0002-3629-8529
Maria Jose OrtegaLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Maria Liz GamarraLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Romeo MontoyaEnfermedades Trasmisibles y Determinantes Ambientales de la Salud CDE/HA/PHE, OPS/OMS, Asuncion 40126, Paraguay.
Evandra Strazza RodriguesBlood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.ORCID 0000-0003-0964-9554
Simone KashimaBlood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Sandra Coccuzzo SampaioButantan Institute, Center for Viral Surveillance and Serological Assessment (CeVIVAS), Sao Paulo 05507-000, SP, Brazil.
Norma ColuchiLaboratorio Central de Salud Pública, Asunción 001535, Paraguay.
Juliana LeiteEmergency Department, Infectious Hazards Management, Pan American Health Organization, Washington, DC 20037, USA.
Lionel GreshEmergency Department, Infectious Hazards Management, Pan American Health Organization, Washington, DC 20037, USA.ORCID 0000-0002-2333-1748
Leticia FrancoEmergency Department, Infectious Hazards Management, Pan American Health Organization, Washington, DC 20037, USA.
José LourençoBiosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal.ORCID 0000-0002-9318-2581
Jairo Mendez RicoEmergency Department, Infectious Hazards Management, Pan American Health Organization, Washington, DC 20037, USA.
Ana Maria Bispo de FilippisLaboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Instituto Osawldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil.
Marta GiovanettiInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-5849-7326

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
NIAID NIH HHS U01 AI151698
6 · The paper itself

Abstract

Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.

Indexed as

DengueDengue VirusGenotypeHumansParaguayPhylogenyRetrospective StudiesSerogroupDENVgenomic surveillanceParaguayphylodymamics

Identifiers

PMID37376575
PMCPMC10304136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.