Evidence map›Paper›PMID 37376558›Full record

ArticleViruses2023

Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis.

Jia He, Liping Yang, Peixi Chang, Shixing Yang, Yu Wang, Shaoli Lin, Qiyi Tang, Yanjin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jia HeMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Liping YangMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Peixi ChangMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Shixing YangMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0001-9899-8291
Yu WangMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Shaoli LinMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Qiyi TangDepartment of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA.ORCID 0000-0002-6487-2356
Yanjin ZhangMolecular Virology Laboratory, Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0002-5847-3260
University of Maryland, College Park · USHoward University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus and causes an infection associated with congenital Zika syndrome and Guillain-Barre syndrome. The mechanism of ZIKV-mediated neuropathogenesis is not well understood. In this study, we discovered that ZIKV induces degradation of the Numb protein, which plays a crucial role in neurogenesis by allowing asymmetric cell division during embryonic development. Our data show that ZIKV reduced the Numb protein level in a time- and dose-dependent manner. However, ZIKV infection appears to have minimal effect on the

Indexed as

FlavivirusZika VirusZika Virus InfectionAnimalsCapsid ProteinsMembrane ProteinsNerve Tissue ProteinsNeurogenesisCapsid ProteinsMembrane ProteinsNerve Tissue ProteinsNUMB protein, humanthe capsid proteinthe Numb proteinZika virusZIKV

Identifiers

PMID37376558
PMCPMC10301363
OpenAlexW4378575671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.