ReviewVaccines2023
Impact of Human Papillomavirus Vaccination on Male Disease: A Systematic Review.
Review in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Strategies implemented to increase HPV vaccine uptake and confidence among men who have sex with men and transgender people: A systematic review.Human vaccines & immunotherapeutics · 2026Pooled it
- Economic evaluation of 22 HPV vaccination strategies to minimize the risk of penile, anal, and oropharyngeal cancers in Chinese males: A Markov model analysis.Human vaccines & immunotherapeutics · 2026Article
- Mapping the global research landscape on HPV vaccine hesitancy: a machine-learning based bibliometric analysis.Virology journal · 2026Article
- Cervical Cancer Screening in Transition: Global Challenges and Local Realities.International journal of women's health · 2026Review
- Review
- Awareness of HPV, HPV vaccine and associated factors among male junior high school students in Zhejiang Province, China.Frontiers in public health · 2026Article
- Human papillomavirus vaccination in men: a crucial step in Ecuadorian public health.Frontiers in public health · 2026Article
- Study of the Knowledge, Attitudes and Practices of Students from Medical Majors Regarding HPV Infections and HPV Vaccines.Pathogens (Basel, Switzerland) · 2025Article
- Cost-effectiveness and epidemiological impact of gender-neutral vaccination against human papillomavirus in economically developed metropolises of Beijing, Shanghai, and Guangzhou, China.Human vaccines & immunotherapeutics · 2025Article
- Addressing male HPV vaccination in China: A narrative review of challenges and opportunities.Human vaccines & immunotherapeutics · 2025Review
- Comprehensive molecular landscape of anal squamous cell carcinoma: analysis of tissue and liquid biopsies from 1844 patients.NPJ precision oncology · 2025Article
- Revisiting HPV vaccination post-COVID: geopolitical, sociocultural, and ethical disparities in global health.International journal for equity in health · 2025Review
- Development and Validation of the Knowledge of Human Papillomavirus Scale in Japan.Healthcare (Basel, Switzerland) · 2025Article
- Primary and Secondary Prophylaxis for Diseases Caused by Human Papillomavirus Infections.Journal of cancer prevention · 2025Review
- Comprehensive Molecular Epidemiology of HPV in a High-Volume Tertiary Center.Infectious diseases & clinical microbiology · 2025Article
- Detection of human papillomavirus in male genital samples.World journal of urology · 2025Observational
- The impact of male contraception on global sexual and reproductive health and rights.Contraception · 2025Review
- Article
- The effects of a protection motivation theory-based online educational program on HPV vaccination intention among female medical students in Hubei province, China: A randomized controlled trial.Journal of education and health promotion · 2025Article
- Breaking barriers: why including boys and men is key to HPV prevention.BMC medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human papillomavirus (HPV)-related diseases are highly prevalent in men worldwide, comprising external anogenital condyloma, anal intraepithelial neoplasia (AIN), penile intraepithelial neoplasia (PIN), and anogenital and oropharyngeal cancers. There is exceptionally low vaccine coverage in the male population. Only 4% of men were fully vaccinated, worldwide, as of 2019. The aim of this review is to assess the impact of HPV vaccination on male disease. Three databases (MEDLINE, Web of Science, Scopus) and Clinical Trials.gov were searched. We included thirteen studies, eight randomized controlled trials (RCTs), and five cohorts, comprising a total of 14,239 participants. Regarding anal disease, seven studies reported HPV vaccine efficacy ranging from 91.1% to 93.1% against AIN1, and ranging from 89.6% to 91.7% against AIN2|3 and anal cancer. Five studies showed an efficacy against genital condyloma of 89.9% in HPV-naïve males, varying between 66.7% and 67.2% in intention-to-treat populations. Studies reporting no efficacy have included older participants. These results support vaccination of young men previously infected, beyond HPV-naïve males. The evidence quality was moderate to low for most outcomes, namely genital diseases. RCTs are needed to assess the efficacy of HPV vaccination on male oropharyngeal cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.