Evidence map›Paper›PMID 37376432›Full record

ArticleVaccines2023

Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Vaccine Formulations Targeting Rabbit Hemorrhagic Disease Virus Are Immunogenic and Efficacious.

Bassel Akache, Andrew J Read, Renu Dudani, Blair A Harrison, Dean Williams, Lise Deschatelets, Yimei Jia, Vandana Chandan, Felicity C Stark, Gerard Agbayani and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Bassel AkacheNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.ORCID 0000-0002-5377-7193
Andrew J ReadVirology Laboratory, Elizabeth Macarthur Agricultural Institute, NSW Department of Primary Industries, Menangle, NSW 2567, Australia.ORCID 0000-0002-2421-4287
Renu DudaniNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Blair A HarrisonNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Dean WilliamsNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Lise DeschateletsNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Yimei JiaNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Vandana ChandanNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Felicity C StarkNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Gerard AgbayaniNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Shawn R MakinenNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Usha D HemrazNational Research Council Canada, Aquatic and Crop Resource Development, Montreal, QC H4P 2R2, Canada.ORCID 0000-0001-5151-9484
Edmond LamNational Research Council Canada, Aquatic and Crop Resource Development, Montreal, QC H4P 2R2, Canada.ORCID 0000-0003-4343-4469
Sophie RégnierNational Research Council Canada, Aquatic and Crop Resource Development, Montreal, QC H4P 2R2, Canada.
Wei ZouNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.
Peter D KirklandVirology Laboratory, Elizabeth Macarthur Agricultural Institute, NSW Department of Primary Industries, Menangle, NSW 2567, Australia.ORCID 0000-0001-8026-4185
Michael J McCluskieNational Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada.ORCID 0000-0001-5538-1363
National Research Council Canada · CANew South Wales Department of Primary Industries · AU

Funding

National Research Council Canada None
6 · The paper itself

Abstract

Vaccines play an important role in maintaining human and animal health worldwide. There is continued demand for effective and safe adjuvants capable of enhancing antigen-specific responses to a target pathogen. Rabbit hemorrhagic disease virus (RHDV) is a highly contagious calicivirus that often induces high mortality rates in rabbits. Herein, we evaluated the activity of an experimental sulfated lactosyl archaeol (SLA) archaeosome adjuvant when incorporated in subunit vaccine formulations targeting RHDV. The subunit antigens consisted of RHDV-CRM

Indexed as

adjuvantarchaeosomerabbit hemorrhagic disease virusRHDVSLAsubunitsulfated lactosyl archaeolvaccine

Identifiers

PMID37376432
PMCPMC10303064
OpenAlexW4378903902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.