Evidence map›Paper›PMID 37376069›Full record

ArticlePharmaceutics2023

Robust Inclusion Complex of Topotecan Comprised within a Rhodamine-Labeled β-Cyclodextrin: Competing Proton and Energy Transfer Processes.

Maria Rosaria Di Nunzio, Abderrazzak Douhal

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria Rosaria Di NunzioDepartamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica and INAMOL, Universidad de Castilla-La Mancha, Av. Carlos III, s/n, 45071 Toledo, Spain.ORCID 0000-0003-2490-5034
Abderrazzak DouhalDepartamento de Química Física, Facultad de Ciencias Ambientales y Bioquímica and INAMOL, Universidad de Castilla-La Mancha, Av. Carlos III, s/n, 45071 Toledo, Spain.ORCID 0000-0003-2247-7566
University of Castilla-La Mancha · ES

Funding

EUROPEAN UNION PID2020-116519RB-I00EUROPEAN UNION PRTR-C17.I1JCCM PRTR-C17.I1JCCM SBPLY/19/180501/000212Ministerio de Ciencia e Innovación PID2020-116519RB-I00
6 · The paper itself

Abstract

Monitoring the biological fate of medicaments within the environments of cancer cells is an important challenge which is nowadays the object of intensive studies. In this regard, rhodamine-based supramolecular systems are one of the most suitable probes used in drug delivery thanks to their high emission quantum yield and sensitivity to the environment which helps to track the medicament in real time. In this work, we used steady-state and time-resolved spectroscopy techniques to investigate the dynamics of the anticancer drug, topotecan (TPT), in water (pH ~6.2) in the presence of a rhodamine-labeled methylated β-cyclodextrin (RB-RM-βCD). A stable complex of 1:1 stoichiometry is formed with a K

Indexed as

anticancer drugsdrug deliveryfluorescent cyclodextrinshost–guest systemsspectroscopy techniques

Identifiers

PMID37376069
PMCPMC10303446
OpenAlexW4382344716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.