Evidence map›Paper›PMID 37375831›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of

Futoon Abedrabbu Al-Rawashde, Ola M Al-Sanabra, Moath Alqaraleh, Ahmad Q Jaradat, Abdullah Saleh Al-Wajeeh, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Epigenetic Reactivation of <italic>SOCS-3</italic> and Inhibition of ERK1/2 Underlie Thymoquinone-Induced Apoptosis in a Chronic Myeloid Leukemia Xenograft Model.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Effects ofCurrent issues in molecular biology · 2024
    Article
  8. Prognostic impact ofTherapeutic advances in hematology · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Futoon Abedrabbu Al-RawashdeDepartment of Anatomy and Histology, Faculty of Medicine, Mutah University, Al-Karak 61710, Jordan.ORCID 0000-0003-1727-5679
Ola M Al-SanabraDepartment of Medical Laboratory Sciences, Faculty of Science, Al-Balqa Applied University, Al-Salt 19117, Jordan.ORCID 0000-0002-9361-9077
Moath AlqaralehPharmacological and Diagnostic Research Center (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.ORCID 0000-0003-2072-2441
Ahmad Q JaradatDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Mutah University, Al-Karak 61710, Jordan.ORCID 0000-0003-2510-9769
Abdullah Saleh Al-WajeehAnti-Doping-Lab Qatar, Doha 27775, Qatar.ORCID 0000-0002-2550-5641
Muhammad Farid JohanDepartment of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.ORCID 0000-0001-6344-0220
Wan Rohani Wan TaibSchool of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Kuala Terengganu 21300, Malaysia.
Imilia IsmailSchool of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Kuala Terengganu 21300, Malaysia.ORCID 0000-0002-3701-4006
Hamid Ali Nagi Al-JamalSchool of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Kuala Terengganu 21300, Malaysia.ORCID 0000-0001-6194-2729
Sultan Zainal Abidin University · MYMutah University · JOAl-Ahliyya Amman University · JOAl-Balqa Applied University · JOAnti-Doping Laboratory · QAUniversiti Sains Malaysia · MY

Funding

Fundamental Research Grant Scheme of the Ministry of Education, Malaysia [FRGS/1/2019/SKK08/UNISZA/02/3 (RR330)].
6 · The paper itself

Abstract

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML).

Indexed as

CMLDNMT1DNMT3ADNMT3BhypomethylationJAK/STATSHP-1TET2thymoquinoneWT1

Identifiers

PMID37375831
PMCPMC10303097
OpenAlexW4380992990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.