ReviewPharmaceuticals (Basel, Switzerland)2023
Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications.
Review in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Organic-Inorganic Hyaluronic Acid/Sumecton Nanocomposite Hydrogels for Osteogenic Applications.Gels (Basel, Switzerland) · 2026Article
- AI-assisted phage formulation delivered via injectable hydrogels for localized control of implant-associated infections.Bioactive materials · 2026Article
- Physicochemical and Mechanical Evaluation of Nanocomposite Cryogels Based on Chitosan and Laponite and Their Potential for Drug Delivery.Gels (Basel, Switzerland) · 2026Article
- Preparation of a Thermosensitive Chitosan-Sea Cucumber Peptide Hydrogel and Its Alleviating Effect on Acute Alcohol-Induced Dual Liver and Brain Injury in Mice.Marine drugs · 2026Article
- Development of PHB-based bio-nanocomposite films with enhanced bioactivity and cytocompatibility for alveolar bone regeneration.RSC advances · 2026Article
- 3D Printing of Bacteriophage-Loaded Hydrogels: Development of a Local and Long-Lasting Delivery System.Advanced healthcare materials · 2026Article
- Poly(Gels (Basel, Switzerland) · 2025Article
- Coupled osteogenesis and angiogenesis on 3D-printed highly porous PCL/magnesium/laponite nanocomposite scaffold.Scientific reports · 2025Article
- Three-Dimensional Printed Hybrid Scaffolds with Layered Polycaprolactone/Nanosized Smectic Clay Nanocomposite and Chitosan/Collagen/Demineralized Bone Powder Hydrogels Targeting Osteochondral Tissue Engineering.Journal of functional biomaterials · 2025Article
- Molecular Design of a Naturally Derived Hemostatic Sealant with Prolonged Antimicrobial Activity for Repairing Elastic Organ Injuries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- LaponitePharmaceutics · 2025Article
- Covalently Functionalized Halloysite-Calixarene Nanotubes for Injectable Hydrogels: A Multicavity Platform for Hydrophobic Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Progressive Hydrogel Applications in Diabetic Foot Ulcer Management: Phase-Dependent Healing Strategies.Polymers · 2025Review
- Optimization of Laponite Nanogel with Curcumin Incorporation: A Quality by Design Approach.Gels (Basel, Switzerland) · 2025Article
- Brillouin Spectroscopy: A Non-Invasive Method for Assessing the Viscoelastic Properties of Biologically Relevant Polymers.Journal of biomedical materials research. Part A · 2025Article
- Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Novel preparation of laponite based theranostic silver nanocomposite for drug delivery, radical scavenging and healing efficiency for wound care management after surgery.Regenerative therapy · 2025Article
- 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release.Drug delivery and translational research · 2024Article
- Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications.ACS nano · 2024Review
- LaponiteMolecules (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hydrogels are widely used for therapeutic delivery applications due to their biocompatibility, biodegradability, and ability to control release kinetics by tuning swelling and mechanical properties. However, their clinical utility is hampered by unfavorable pharmacokinetic properties, including high initial burst release and difficulty in achieving prolonged release, especially for small molecules (<500 Da). The incorporation of nanomaterials within hydrogels has emerged as viable option as a method to trap therapeutics within the hydrogel and sustain release kinetics. Specifically, two-dimensional nanosilicate particles offer a plethora of beneficial characteristics, including dually charged surfaces, degradability, and enhanced mechanical properties within hydrogels. The nanosilicate-hydrogel composite system offers benefits not obtainable by just one component, highlighting the need for detail characterization of these nanocomposite hydrogels. This review focuses on Laponite, a disc-shaped nanosilicate with diameter of 30 nm and thickness of 1 nm. The benefits of using Laponite within hydrogels are explored, as well as examples of Laponite-hydrogel composites currently being investigated for their ability to prolong the release of small molecules and macromolecules such as proteins. Future work will further characterize the interplay between nanosilicates, hydrogel polymer, and encapsulated therapeutics, and how each of these components affect release kinetics and mechanical properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.