Unveiling the Potential of BenzylethyleneAryl-Urea Scaffolds for the Design of New Onco Immunomodulating Agents.

Raquel Gil-Edo, Santiago Royo, Miguel Carda, Eva Falomir

Open access · goldAbstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.7field-weighted citation impact, top 28% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raquel Gil-EdoInorganic and Organic Chemistry Department, University Jaume I, 12071 Castellón, Spain.ORCID 0000-0002-2977-7783

Santiago RoyoInstitute of Agronomic Engineering for Development, Polytechnic University of Valencia, 46022 Valencia, Spain.

Miguel CardaInorganic and Organic Chemistry Department, University Jaume I, 12071 Castellón, Spain.

Eva FalomirInorganic and Organic Chemistry Department, University Jaume I, 12071 Castellón, Spain.ORCID 0000-0003-0329-6313

Universitat Jaume I · ESUniversitat Politècnica de València · ES

Funding

Asociación Española Contra el Cáncer PRDCA18002CARDJaume I University UJI-B2021-46Ministry of Economy, Industry and Competitiveness PID2021-1267770B-100Ministry of Economy, Industry and Competitiveness RTI2018-097345-B-I00

6 · The paper itself

Abstract

This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, and cancer ones, such as HT-29, MCF-7 or A-549, on the immune Jurkat T-cells and endothelial cells HMEC-1. Compounds

Indexed as

angiogenesisaryl ureaCD-11bCD-80co-culturesHT-29immune checkpointsPD-L1THP-1tumor microenvironmentVEGFR-2

Identifiers

PMID37375756

DOI10.3390/ph16060808

PMCPMC10302582

OpenAlexW4381572610

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.