Evidence map›Paper›PMID 37375405›Full record

ArticleMolecules (Basel, Switzerland)2023

The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy.

Shuai Zhang, Yilei Zheng, Hong Du, Wei Zhang, Haohuan Li, Yangping Ou, Funeng Xu, Juchun Lin, Hualin Fu, Xueqing Ni and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Shuai ZhangDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Yilei ZhengCenter for Veterinary Sciences, Zhejiang University, Hangzhou 310030, China.
Hong DuDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Wei ZhangDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Haohuan LiDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Yangping OuDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Funeng XuDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Juchun LinDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Hualin FuDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Xueqing NiAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Li-Jen ChangDepartment of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.
Gang ShuDepartment of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu 611100, China.
Sichuan Agricultural University · CNVirginia–Maryland College of Veterinary Medicine · USZhejiang University · CN

Funding

Regional Innovation Cooperation project of Sichuan province 2023YFQ0050Sichuan Province to promote rural revitalization of science and technology projects 2022ZHXC0019
6 · The paper itself

Abstract

The excessive intake of fluoride, one of the trace elements required to maintain health, leads to liver injury. Tetramethylpyrazine (TMP) is a kind of traditional Chinese medicine monomer with a good antioxidant and hepatoprotective function. The aim of this study was to investigate the effect of TMP on liver injury induced by acute fluorosis. A total of 60 1-month-old male ICR mice were selected. All mice were randomly divided into five groups: a control (K) group, a model (F) group, a low-dose (LT) group, a medium-dose (MT) group, and a high-dose (HT) group. The control and model groups were given distilled water, while 40 mg/kg (LT), 80 mg/kg (MT), or 160 mg/kg (HT) of TMP was fed by gavage for two weeks, with a maximum gavage volume for the mice of 0.2 mL/10 g/d. Except for the control group, all groups were given fluoride (35 mg/kg) by an intraperitoneal injection on the last day of the experiment. The results of this study showed that, compared with the model group, TMP alleviated the pathological changes in the liver induced by the fluoride and improved the ultrastructure of liver cells; TMP significantly decreased the levels of ALT, AST, and MDA (

Indexed as

FluoridesLiver DiseasesAnimalsLiverMaleMiceMice, Inbred ICRNF-E2-Related Factor 2Oxidative StressPyrazinesRNA, MessengerSuperoxide DismutaseFluoridesNF-E2-Related Factor 2PyrazinesRNA, MessengerSuperoxide Dismutasetetramethylpyrazineacute fluorosisliverNrf2oxidative damagetetramethylpyrazine

Identifiers

PMID37375405
PMCPMC10302661
OpenAlexW4381434816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.