Evidence map›Paper›PMID 37375382›Full record

ArticleMolecules (Basel, Switzerland)2023

New Insights into the Opioid Analgesic Profile of

Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl-Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Giuliana CostanzoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.ORCID 0000-0002-9510-6371
Rita TurnaturiDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-5895-7820
Carmela ParentiDepartment of Drug and Health Sciences, Section of Pharmacology and Toxicology, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0003-1412-2597
Salvatore SpotoDepartment of Drug and Health Sciences, Section of Pharmacology and Toxicology, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0009-0008-6431-0709
Silvia PianaDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-6951-7628
Maria DichiaraDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-6380-7176
Chiara ZagniDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0003-1220-4281
Anna Rita GalambosDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0009-0001-5539-9595
Nariman EssmatDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0000-0003-3440-6263
Agostino MarrazzoDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-8728-8857
Emanuele AmataDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0002-4750-3479
Mahmoud Al-KhrasaniDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.ORCID 0000-0001-8488-3266
Lorella PasquinucciDepartment of Drug and Health Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0003-1309-3368
University of Catania · ITSemmelweis University · HU

Funding

Semmelweis University TKP2021University of Catania UPB 57722172125
6 · The paper itself

Abstract

In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the

Indexed as

Analgesics, OpioidReceptors, Opioid, muAnimalsCyclazocineEnkephalin, Ala(2)-MePhe(4)-Gly(5)-LigandsMaleMicePainRatsAnalgesics, OpioidCyclazocineEnkephalin, Ala(2)-MePhe(4)-Gly(5)-LigandsnormetazocineReceptors, Opioid, muCFA testcompetition binding assaymouse vas deferens assaytail-flick testμ opioid receptor

Identifiers

PMID37375382
PMCPMC10301092
OpenAlexW4381149060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.