Evidence map›Paper›PMID 37375346›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis of Methylgenipin and Evaluation of Its Anti-Hepatic Injury Activity.

Jingjing Wang, Yongwei Qiu, Yaohui Chen, Feng Zhou, Shuaikang Wang, Liping Chen, Yinfang Chen, Riyue Yu, Liping Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jingjing WangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Yongwei QiuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Yaohui ChenJiangxi Provincial People's Hospital, Nanchang 330012, China.
Feng ZhouJiangxi Provincial People's Hospital, Nanchang 330012, China.
Shuaikang WangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liping ChenSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Yinfang ChenSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Riyue YuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liping HuangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.ORCID 0000-0002-8120-8342
Jiangxi University of Traditional Chinese Medicine · CNJiangxi Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genipin has been the focus of research as a multifunctional compound for the treatment of pathogenic diseases. However, hepatotoxicity caused by oral genipin raises concerns about its safety. To obtain novel derivatives with low toxicity and efficacy, we synthesized methylgenipin (MG), a new compound, using structural modification, and investigated the safety of MG administration. The results showed that the LD

Indexed as

Chemical and Drug Induced Liver InjuryCholestasisAnimalsAntioxidantsGlutathioneIridoidsLiverMiceAntioxidantsgenipinGlutathioneIridoidsANITgenipinliver injurymethylgenipin (MG)structural modification

Identifiers

PMID37375346
PMCPMC10303713
OpenAlexW4380990621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.