Evidence map›Paper›PMID 37374999›Full record

ArticleMicroorganisms2023

Impact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis.

Lanxin Zhang, Samantha Manning, Tong Tong Wu, Yan Zeng, Aaron Lee, Yan Wu, Bruce J Paster, George Chen, Kevin Fiscella, Jin Xiao

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lanxin ZhangDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Samantha ManningDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14627, USA.
Tong Tong WuDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14627, USA.
Yan ZengEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA.
Aaron LeeEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA.
Yan WuEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA.ORCID 0000-0002-6693-9657
Bruce J PasterDepartment of Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.
George ChenDepartment of Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.ORCID 0000-0001-6689-317X
Kevin FiscellaDepartment of Family Medicine, University of Rochester Medical Center, Rochester, NY 14627, USA.
Jin XiaoEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA.
University of Rochester Medical Center · USUniversity of California, Berkeley · US

Funding

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancyR01DE031025 · NIDCR · UNIVERSITY OF ROCHESTER · PI STEVEN R. GILL, Tongtong Wu · 2022 to 2026
$3.9M
Association between Oral Candida albicans and the Onset of Severe Early Childhood CariesK23DE027412 · NIDCR · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2018 to 2022
$748k
NIDCR NIH HHS K23 DE027412NIDCR NIH HHS K23DE027412 and R01DE031025NIDCR NIH HHS R01 DE031025
6 · The paper itself

Abstract

This study aimed to evaluate the impact of Nystatin oral rinse on salivary and supragingival microbiota in adults with oral candidiasis and identify predictive factors related to individuals' responses to Nystatin. The trial involved twenty participants who used 600,000 International Units/application of Nystatin oral rinse for seven days, four times a day, and were followed up at one week and three months after the rinse. The salivary and plaque microbiome of the participants were assessed via 16S rDNA amplicon sequencing. Overall, salivary and plaque microbiomes remained stable. However, among the participants (53 percent) who responded to Nystatin rinse (defined as free of oral

Indexed as

ActinomycesNystatinoral microbial analysisPrevotellaStreptococcusVeillonella

Identifiers

PMID37374999
PMCPMC10303349
OpenAlexW4379471738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.