ArticleMicroorganisms2023
Roles of Cysteine Proteases in Biology and Pathogenesis of Parasites.
Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dual RNA-seq Identifies Virulence Factors in Mesanophrys sp. and Immune Defenses in Portunus trituberculatus Hemocytes.Acta parasitologica · 2026Article
- Decoding the Pine Wood Nematode's survival mystery: Gene family expansion drives adaptation revealed by dual-omics.PLoS pathogens · 2026Article
- To Explore Potential Natural Inhibitors of Cysteine Proteases to Combat Human African Trypanosomiasis and Chagas Disease.Current medicinal chemistry · 2026Review
- Chemical perturbation reveals a cytoskeletal-trafficking vulnerability inFrontiers in pharmacology · 2026Article
- Proteases fromJournal of fungi (Basel, Switzerland) · 2025Review
- The CRISPR-Cas9 System inMicroorganisms · 2025Article
- Cysteine proteases and how YabG fits into clan CD of the MEROPS database.Journal of bacteriology · 2025Review
- Structural and functional characterization of IdeC, a novel IgG-specific protease ofInfection and immunity · 2025Article
- Transmission Dynamics ofMicroorganisms · 2025Article
- Construction, expression, and characterization of scFv fragment against Fasciola gigantica cathepsin L1H.Parasitology research · 2025Article
- Jasmonic Acid (JA) Signaling Pathway in Rice Defense Against Chilo suppressalis Infestation.Rice (New York, N.Y.) · 2025Review
- Characteristics and immunoprotective functions of three cysteine proteases fromFrontiers in immunology · 2025Article
- Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment.Current drug targets · 2025Review
- A genome-wide investigation ofFrontiers in microbiology · 2025Article
- New Pipeline for Analysing Fruit Proteolytic Products Used as Digestive Health Nutraceuticals.International journal of molecular sciences · 2024Article
- Advances in the Search for SARS-CoV-2 MPathogens (Basel, Switzerland) · 2024Review
- The Low Genetic Diversity of Dientamoeba fragilis Isolates in Southwest Turkey and Analysis of Clinical Findings.Acta parasitologica · 2024Article
- Therapeutic Effect of Lecigel, CetiolInternational journal of molecular sciences · 2024Article
- Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation.Frontiers in immunology · 2024Article
- Development and therapeutic evaluation of 5D3(CC-MLN8237)Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cysteine proteases, also known as thiol proteases, are a class of nucleophilic proteolytic enzymes containing cysteine residues in the enzymatic domain. These proteases generally play a pivotal role in many biological reactions, such as catabolic functions and protein processing, in all living organisms. They specifically take part in many important biological processes, especially in the absorption of nutrients, invasion, virulence, and immune evasion of parasitic organisms from unicellular protozoa to multicellular helminths. They can also be used as parasite diagnostic antigens and targets for gene modification and chemotherapy, as well as vaccine candidates, due to their species and even life-cycle stage specificity. This article highlights current knowledge on parasitic cysteine protease types, biological functions, and their applications in immunodiagnosis and chemotherapy.
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