Evidence map›Paper›PMID 37374759›Full record

ArticleMicromachines2023

Visible Pulsed Laser-Assisted Selective Killing of Cancer Cells with PVP-Capped Plasmonic Gold Nanostars.

Aniket Mishra, Rafia Inaam, Shunya Okamoto, Takayuki Shibata, Tuhin Subhra Santra, Moeto Nagai

Abstract read
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aniket MishraDepartment of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.
Rafia InaamDepartment of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.
Shunya OkamotoDepartment of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.
Takayuki ShibataDepartment of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.ORCID 0000-0003-0972-2950
Tuhin Subhra SantraDepartment of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, India.ORCID 0000-0002-9403-2155
Moeto NagaiDepartment of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.ORCID 0000-0002-7852-7772

Funding

Japan Society for the Promotion of Science KAKENHI JP 20H02115 and 23H00168
6 · The paper itself

Abstract

A new generation of nanoscale photosensitizer agents has improved photothermal capabilities, which has increased the impact of photothermal treatments (PTTs) in cancer therapy. Gold nanostars (GNS) are promising for more efficient and less invasive PTTs than gold nanoparticles. However, the combination of GNS and visible pulsed lasers remains unexplored. This article reports the use of a 532 nm nanosecond pulse laser and polyvinylpyrrolidone (PVP)-capped GNS to kill cancer cells with location-specific exposure. Biocompatible GNS were synthesized via a simple method and were characterized under FESEM, UV-visible spectroscopy, XRD analysis, and particle size analysis. GNS were incubated over a layer of cancer cells that were grown in a glass Petri dish. A nanosecond pulsed laser was irradiated on the cell layer, and cell death was verified via propidium iodide (PI) staining. We assessed the effectiveness of single-pulse spot irradiation and multiple-pulse laser scanning irradiation in inducing cell death. Since the site of cell killing can be accurately chosen with a nanosecond pulse laser, this technique will help minimize damage to the cells around the target cells.

Indexed as

less invasivenanosecond pulse laserphotothermal treatmentPVP capped gold nanostars

Identifiers

PMID37374759
PMCPMC10305603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.