Evidence map›Paper›PMID 37374127›Full record

ArticleLife (Basel, Switzerland)2023

Age and Gender Trends in the Prevalence of Markers for Hepatitis E Virus Exposure in the Heterogeneous Bulgarian Population.

Elitsa Golkocheva-Markova, Chiydem Ismailova, Ani Kevorkyan, Ralitsa Raycheva, Sashka Zhelyazkova, Stanislav Kotsev, Maria Pishmisheva, Vanya Rangelova, Asya Stoyanova, Viliana Yoncheva and 7 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hepatitis E virus infections in German blood donors: results of 8 years of screening, 2015 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Elitsa Golkocheva-MarkovaNRL Hepatitis Viruses, Department of Virology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.ORCID 0000-0002-3462-866X
Chiydem IsmailovaNRL Hepatitis Viruses, Department of Virology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Ani KevorkyanDepartment of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University, 4002 Plovdiv, Bulgaria.
Ralitsa RaychevaDepartment of Social Medicine and Public Health, Faculty of Public Health, Medical University, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-6417-5681
Sashka ZhelyazkovaClinic of Nervous Diseases, University Hospital "Alexandrovska", Medical University, 1431 Sofia, Bulgaria.ORCID 0000-0001-5295-6774
Stanislav KotsevDepartment Infectious Diseases, Regional Hospital, 4400 Pazardzhik, Bulgaria.ORCID 0000-0001-8201-0242
Maria PishmishevaDepartment Infectious Diseases, Regional Hospital, 4400 Pazardzhik, Bulgaria.ORCID 0000-0001-6792-9146
Vanya RangelovaDepartment of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University, 4002 Plovdiv, Bulgaria.ORCID 0000-0001-9270-5996
Asya StoyanovaNRL Enteroviruses, Department of Virology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.ORCID 0000-0001-6219-8524
Viliana YonchevaNRL Hepatitis Viruses, Department of Virology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Tencho TenevNRL Hepatitis Viruses, Department of Virology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Teodora GladnishkaNRL of Vector-Borne Infections, Listeria and Leptospires, Department of Microbiology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Iva TrifonovaNRL of Vector-Borne Infections, Listeria and Leptospires, Department of Microbiology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.ORCID 0000-0002-7320-9548
Iva ChristovaNRL of Vector-Borne Infections, Listeria and Leptospires, Department of Microbiology, National Center of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
Roumen DimitrovInstitute of Mathematics and Informatics, Bulgarian Academy of Sciences, 1000 Sofia, Bulgaria.
Roberto BruniDepartment of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-3035-5510
Anna Rita CiccaglioneDepartment of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
National Center of Infectious and Parasitic Diseases · BGMedical University Plovdiv · BGIstituto Superiore di Sanità · ITAlexandrovska Hospital · BGBulgarian Academy of Sciences · BG

Funding

National Science Fund of Bulgaria KP-06-N33/2
6 · The paper itself

Abstract

The prevalence of hepatitis E virus (HEV) in the Bulgarian population remains underestimated. The aim of the present study was to evaluate age and gender trends in HEV prevalence in the heterogeneous Bulgarian population. Stored serum samples from blood donors and different patient sub-populations-kidney recipients (KR), patients with Guillain-Barre syndrome (GBS), Lyme disease (LD), patients with liver involvement and a clinical diagnosis other than viral hepatitis A and E (non-AE), hemodialysis (HD) and HIV-positive patients (HIV)-were retrospectively investigated for markers of past and recent/ongoing HEV infection. The estimated overall seroprevalence of past infection was 10.6%, ranging from 5.9% to 24.5% for the sub-populations evaluated, while the seroprevalence of recent/ongoing HEV infection was 7.5%, ranging from 2.1% to 20.4%. The analysis of the individual sub-populations showed a different prevalence with respect to sex. In regard to age, the cohort effect was preserved, as a multimodal pattern was observed only for the GBS sub-population. Molecular analysis revealed HEV 3f and 3e. The type of the population is one of the main factors on which the anti-HEV prevalence depends, highlighting the need for the development of guidelines related to the detection and diagnosis of HEV infection with regard to specific patient populations.

Indexed as

hepatitis Eheterogeneous populationpast infectionprevalencerecent/ongoing infection

Identifiers

PMID37374127
PMCPMC10301971
OpenAlexW4380050327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.