ReviewLife (Basel, Switzerland)2023
Immunomodulatory Effects of Natural Feed Additives for Meat Chickens.
Review in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Medicinal Plants in Poultry During Post-Antibiotic Era in One-Health Approach: An Extensive Review.Veterinary medicine and science · 2026Review
- Effects of Superdose phytase and acidifier supplementation in a phosphorus-deficient diet on growth performance, carcass characteristics, Cecal microbiota, and intestinal and liver morphology in broiler chickens.Veterinary and animal science · 2026Article
- A Comparative Study of Formic Acid, Herbal Mixture and Spirulina Powder as Antibiotic Alternatives in Broiler Diets: Effects on Growth, Carcass Traits, Blood Biochemistry and Microbial Load.Veterinary medicine and science · 2026Article
- Dietary effects of duckweed on performance, carcass characteristics, hematology, immunity, sensory traits, and fatty acid profile of meat in broilers.Scientific reports · 2026Article
- Improving the composition and drying techniques of "Cinnamononi" extract as a natural feed supplement to enhance carcass and broiler performance.Open veterinary journal · 2026Article
- Dose-dependent effects of dietary quercetin on cecal microbiota, hematological responses, and production efficiency in Arbor Acres broiler chickens.Veterinary world · 2026Article
- Nano zinc supplementation in broiler nutrition: current evidence, mechanisms of action, and future perspectives.Frontiers in veterinary science · 2026Review
- Efficacy of Aqueous Moringa Oleifera Leaf Extract as a Natural Alternative to Antibiotics in Broiler Chickens: Impacts on Growth, Digestibility, and Blood Lipid Profile.Veterinary sciences · 2025Article
- Chlorogenic acid alters ileal microbiota and metabolites in broiler chickens under immune stress.Microbiology spectrum · 2025Article
- Effects of Zataria multiflora, Salvia officinalis and Probiotics on Intestinal Microbial Colonization, Immunocompetence, Jejunal Histology and Performance of Laying Hens.Veterinary medicine and science · 2025Article
- Dietary supplementation of coffee pulp extract enhances growth performance and intestinal morphology in broiler chicken.Poultry science · 2025Article
- Effects ofAnimals : an open access journal from MDPI · 2025Article
- Effects of Different Levels ofAntioxidants (Basel, Switzerland) · 2025Article
- Effect of dietary supplementation withFrontiers in veterinary science · 2025Article
- Initial Evaluation of Safety and Immunomodulatory Potential of Dietary Supplementation with Mangosteen Pericarp Extract for Sustainable Meat Production in Native Crossbred Chickens.Life (Basel, Switzerland) · 2024Article
- Review
- Influence of feed supplementation with probiotic and organic form of zinc on functional status of broiler chickens.Open veterinary journal · 2024Article
- Feed additives and enrichment materials to reduce chicken stress, maximize productivity, and improve welfare.Veterinary world · 2024Review
- Mechanochemical Synthesis of Resveratrol-Piperazine Cocrystals.Materials (Basel, Switzerland) · 2024Article
- Lactulose with synergists supplementation improving a health of chicks and reducing the environmental burden in poultry industry.Journal of advanced veterinary and animal research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Broiler chickens are increasingly kept in large numbers in intensive housing conditions that are stressful, potentially depleting the immune system. With the prohibition of the use of antibiotics in poultry feed spreading worldwide, it is necessary to consider the role of natural feed additives and antibiotic alternatives to stimulate the chickens' immune systems. We review the literature to describe phytogenic feed additives that have immunomodulatory benefits in broilers. We initially review the major active ingredients from plants, particularly flavonoids, resveratrol and humic acid, and then describe the major herbs, spices, and other plants and their byproducts that have immunomodulatory effects. The research reviewed demonstrates the effectiveness of many natural feed additives in improving the avian immune system and therefore broiler health. However, some, and perhaps all, additives have the potential to reduce immunocompetence if given in excessive amounts. Sometimes additives are more effective when given in combination. There is an urgent need to determine tolerance levels and optimum doses for additives deemed most suitable to replace antibiotics in the diet of broiler chickens. Effective replacement is most likely with readily available additives, such as olive oil byproducts, olive leaves and alfalfa. It is concluded that effective replacement of antibiotic function with plant-derived additives will be possible, but that further research is necessary to determine optimum doses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.