Evidence map›Paper›PMID 37374043›Full record

ReviewLife (Basel, Switzerland)2023

Mechanisms of Atrial Fibrillation: How Our Knowledge Affects Clinical Practice.

Georgios Leventopoulos, Rafail Koros, Christoforos Travlos, Angelos Perperis, Panagiotis Chronopoulos, Evropi Tsoni, Eleni-Evangelia Koufou, Athanasios Papageorgiou, Anastasios Apostolos, Panagiotis Kaouris and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  11. Atrial fibrillation and flutter in the Eastern Mediterranean: burden, disparities, and risk factor contributions from 1990 to 2021.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Georgios LeventopoulosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-3982-5101
Rafail KorosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-6890-5127
Christoforos TravlosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-7797-8141
Angelos PerperisCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Panagiotis ChronopoulosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Evropi TsoniCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Eleni-Evangelia KoufouCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0001-8979-8554
Athanasios PapageorgiouCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Anastasios ApostolosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0003-2616-7952
Panagiotis KaourisCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Periklis DavlourosCardiology Department, University Hospital of Patras, 26504 Patras, Greece.
Grigorios TsigkasCardiology Department, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-2779-0765
General University Hospital of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is a very common arrhythmia that mainly affects older individuals. The mechanism of atrial fibrillation is complex and is related to the pathogenesis of trigger activation and the perpetuation of arrhythmia. The pulmonary veins in the left atrium arei confirm that onfirm the most common triggers due to their distinct anatomical and electrophysiological properties. As a result, their electrical isolation by ablation is the cornerstone of invasive AF treatment. Multiple factors and comorbidities affect the atrial tissue and lead to myocardial stretch. Several neurohormonal and structural changes occur, leading to inflammation and oxidative stress and, consequently, a fibrotic substrate created by myofibroblasts, which encourages AF perpetuation. Several mechanisms are implemented into daily clinical practice in both interventions in and the medical treatment of atrial fibrillation.

Indexed as

atrial fibrillationfibrosisinflammation oxidative stresstriggers

Identifiers

PMID37374043
PMCPMC10303005
OpenAlexW4378378516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.