Evidence map›Paper›PMID 37374013›Full record

ArticleLife (Basel, Switzerland)2023

Hydrogen Peroxide, Povidone-Iodine and Chlorhexidine Fail to Eradicate

Dana M Parker, John A Koch, Charles G Gish, Kimberly M Brothers, William Li, Jessica Gilbertie, Sarah E Rowe, Brian P Conlon, Venkata K C Byrapogu, Kenneth L Urish

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Activity of Antiseptics AgainstAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dana M ParkerArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
John A KochArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5692-7970
Charles G GishArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kimberly M BrothersArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2055-9760
William LiArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jessica GilbertieCenter for One Health Research, Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060, USA.
Sarah E RoweDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8955-359X
Brian P ConlonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Venkata K C ByrapoguArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kenneth L UrishArthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
University of Pittsburgh · USUniversity of North Carolina at Chapel Hill · USEdward Via College of Osteopathic Medicine · US

Funding

University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
The Role of Teichoic Acid Glycosylation in Phage Activity and Selection in an Ongoing FDA Phase II/III Clinical Study of Bacteriophage Therapy in Chronic Periprosthetic Joint InfectionR01AR082167 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOUB, JAMES B., URISH, KENNETH L · 2022 to 2025
$1.6M
Biofilm antibiotic tolerance in periprosthetic joint infectionK08AR071494 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URISH, KENNETH L · 2017 to 2021
$831k
The Role of Biofilm Formation in Antibiotic Tolerant Periprosthetic Joint InfectionR03AR077602 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URISH, KENNETH L · 2021 to 2022
$158k
NCATS NIH HHS KL2 TR000146NCATS NIH HHS NCATS KL2TR000146NIAMS NIH HHS K08 AR071494NIAMS NIH HHS NIAMS K08AR071494NIAMS NIH HHS R01 AR082167NIAMS NIH HHS R03 AR077602NIAMS NIH HHS R03AR077602
6 · The paper itself

Abstract

Hydrogen peroxide, povidone-iodine, and chlorhexidine are antiseptics that are commonly added to irrigants to either prevent or treat infection. There are little clinical data available that demonstrate efficacy of adding antiseptics to irrigants in the treatment of periprosthetic joint infection after biofilm establishment. The objective of the study was to assess the bactericidal activity of the antiseptics on

Indexed as

antibiotic tolerancebiofilmoxidative stressperiprosthetic joint infectionsurgical infection

Identifiers

PMID37374013
PMCPMC10304975
OpenAlexW4378083231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.