Evidence map›Paper›PMID 37373926›Full record

ArticleJournal of personalized medicine2023

Improving Functional Capacity and Quality of Life in Parkinson's Disease Patients through REAC Neuromodulation Treatments for Mood and Behavioral Disorders.

Chiara Rinaldi, Cleuton Braga Landre, Maria Izabel Volpe, Rebeca Góes Gonçalves, Lucas Dos Santos Nunes, Danyela Darienso, Ana Vitoria Cruz, João Douglas Oliveira, Salvatore Rinaldi, Vania Fontani and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07373366 (Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07373366 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer (REAC) in Diffuse Axonal Injury: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of Sao PauloRan2025 to 2027Enrolled60ConditionsTraumatic Brain InjuryArmsSubjects in the intervention group receive low-frequency radioelectric therapy, Sham, the device simulates a therapy session
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Chiara RinaldiDepartment of Neuroscience, Psychology, Drug Area, and Child Health (NEUROFARBA), University of Florence, 50121 Florence, Italy.ORCID 0000-0002-7675-0313
Cleuton Braga LandreDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
Maria Izabel VolpeDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
Rebeca Góes GonçalvesDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
Lucas Dos Santos NunesDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
Danyela DariensoDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
Ana Vitoria CruzDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.
João Douglas OliveiraDepartment of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.ORCID 0000-0002-8630-6742
Salvatore RinaldiDepartment of Regenerative Medicine, Rinaldi Fontani Institute, 50144 Florence, Italy.ORCID 0000-0002-8961-6316
Vania FontaniDepartment of Regenerative Medicine, Rinaldi Fontani Institute, 50144 Florence, Italy.ORCID 0000-0003-0141-6270
Ana Rita BarcessatGraduate Program in Health Sciences-PPGCS, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.ORCID 0000-0002-5261-6435
Universidade Federal do Amapá · BRDeutsches Historisches Institut Rom · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a neurological disorder that affects both motor and non-motor functions, including depression, anxiety, and cognitive decline. Currently, it remains a challenge to distinguish the correlation between these aspects and their impact on one another. To try to clarify these reciprocal influences, in this study we have used specific radio electric asymmetric conveyer (REAC) technology neuromodulation treatments for behavioral mood disorders and adjustment disorders. In particular, we employed the neuro-postural optimization (NPO) and neuro-psycho-physical optimization (NPPOs) treatments. The study enrolled randomly 50 subjects of both genders previously diagnosed with Parkinson's disease for at least six months. Prior to and following REAC NPO and NPPOs treatments, we assessed the subjects using functional dysmetria (FD) evaluation, five times sit to stand test (FTSST) for postural stability, and the 12-item Short-Form Health Survey (SF-12) for quality of life (QLF) evaluation. The positive results produced by the REAC NPO and NPPOs neuromodulation treatments, specific for mood and adaptation disorders, on dysfunctional motor disorders, and quality of life confirm how the non-motor components can condition the symptomatology of Parkinsonian motor symptoms. These results also highlight the usefulness of REAC NPO and NPPOs treatments in improving the overall quality of life of these patients.

Indexed as

mood and behavioral disordersmotor symptomsneuromodulationnon-motor symptomsParkinsonradio electric asymmetric conveyer technology

Identifiers

PMID37373926
PMCPMC10305197
OpenAlexW4381678559

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.