Evidence map›Paper›PMID 37373907›Full record

ArticleJournal of personalized medicine2023

Pharmacogenetics of Lethal Opioid Overdose: Review of Current Evidence and Preliminary Results from a Pilot Study.

Leen Magarbeh, Ilona Gorbovskaya, Richard Wells, Reuven Jhirad, Bernard Le Foll, Daniel J Müller

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The Rise of Fentanyl: Molecular Aspects and Forensic Investigations.International journal of molecular sciences · 2025
    Review
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leen MagarbehDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-4310-928X
Ilona GorbovskayaCentre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Richard WellsOffice of the Chief Coroner and Ontario Forensic Pathology Service, Toronto, ON M3M 0B1, Canada.
Reuven JhiradOffice of the Chief Coroner and Ontario Forensic Pathology Service, Toronto, ON M3M 0B1, Canada.
Bernard Le FollDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-6406-4973
Daniel J MüllerDepartment of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Centre for Addiction and Mental Health · CAOffice of the Chief Medical Examiner · CA

Funding

CAMH-AHSC AFP Innovation fund CAM-19-002
6 · The paper itself

Abstract

There has been a worldwide substantial increase in accidental opioid-overdose deaths. The aim of this review, along with preliminary results from our pilot study, is to highlight the use of pharmacogenetics as a tool to predict causes of accidental opioid-overdose death. For this review, a systematic literature search of PubMed

Indexed as

CYP450opioidsoverdosepharmacogeneticspost-mortem

Identifiers

PMID37373907
PMCPMC10302877
OpenAlexW4378905604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.