Evidence map›Paper›PMID 37373839›Full record

ArticleJournal of clinical medicine2023

CABG Patients Develop Global DNA Hypermethylation, That Negatively Affect the Mitochondrial Function and Promote Post-Surgical Cognitive Decline: A Proof of Concept in Small Cohort.

Sri Rahavi Boovarahan, Suresh Babu Kale, Priyanka N Prem, Sriram Ravindran, Akshayakeerthi Arthanarisami, Jeyashri Rengaraju, Nemat Ali, Senthilkumar Ramalingam, Mohamed Mohany, Abdullah F AlAsmari and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Mitochondrial Dysfunction in Cardiac Surgery.Anesthesiology clinics · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Sri Rahavi BoovarahanVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.
Suresh Babu KaleDepartment of Cardiovascular and Thoracic Surgery, Meenakshi Hospital Tanjore, Thanjavur 613005, India.
Priyanka N PremVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.
Sriram RavindranVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.ORCID 0000-0003-4829-3626
Akshayakeerthi ArthanarisamiVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.ORCID 0000-0003-1183-9920
Jeyashri RengarajuVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.
Nemat AliDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-6525-4202
Senthilkumar RamalingamDepartment of Cardiovascular and Thoracic Surgery, Meenakshi Hospital Tanjore, Thanjavur 613005, India.
Mohamed MohanyDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-7709-5253
Abdullah F AlAsmariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-7569-4287
Salim S Al-RejaieDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.
Mohammad WaseemDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA.ORCID 0000-0002-1708-0137
Gino A KurianVascular Biology Laboratory, SASTRA Deemed University, Thanjavur 613401, India.
SASTRA University · INKing Saud University · SAUniversity of Maryland Eastern Shore · US

Funding

King Saud University RSPD2023R758
6 · The paper itself

Abstract

Global DNA hypermethylation and mitochondrial dysfunction are reported to be associated with the development of mild cognitive decline (MCI). The present study aims to generate preliminary data that connect the above association with post-surgical coronary artery bypass grafting (CABG) cognitive decline in patients. Data were collected from 70 CABG patients and 25 age-matched controls. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) test on day 1 (before surgery) and on the day of discharge. Similarly, blood was collected before and one day after the CABG procedure for mitochondrial functional analysis and expression of DNA methylation genes. Test analysis score suggested 31 (44%) patients had MCI before discharge. These patients showed a significant decrease in complex I activity and an increase in malondialdehyde levels (

Indexed as

DNA methylationischemia-reperfusion injurymild cognitive impairmentmitochondrial functionoff-pump CABGperipheral blood mononuclear cells

Identifiers

PMID37373839
PMCPMC10299456
OpenAlexW4381434972

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.